Evidence map›Paper›PMID 32616024›Full record

ArticleBMC research notes2020

Frequency distribution of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) polymorphisms among healthy Sudanese population.

Nouh S Mohamed, Emmanuel E Siddig, Abdallah E Ahmed, Musab M A Albsheer, Hanadi Abdelbagi, Eman T Ali, Anadel A Alsubki, Sabah A Abdalaziz, Madinna Mustafa, Mohamed S Muneer and 6 more

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In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nouh S MohamedDepartment of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan. nouh_saad@outlook.com.ORCID http://orcid.org/0000-0001-6843-3361
Emmanuel E SiddigAlfarrabi College for Science and Technology, Khartoum, Sudan.
Abdallah E AhmedAlfarrabi College for Science and Technology, Khartoum, Sudan.
Musab M A AlbsheerDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Sinnar University, Sinnar, Sudan.
Hanadi AbdelbagiDepartment of Biotechnology, School of Pharmacy, Ahfad University for Women, Omdurman, Sudan.
Eman T AliDepartment of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Anadel A AlsubkiDepartment of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan.
Sabah A AbdalazizDepartment of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan.
Madinna MustafaDepartment of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile University, Khartoum, Sudan.
Mohamed S MuneerDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Hussam A OsmanDepartment of Biotechnology, School of Pharmacy, Ahfad University for Women, Omdurman, Sudan.
Maha M OsmanAlfarrabi College for Science and Technology, Khartoum, Sudan.
Mohamed S AliFaculty of Medicine, Neelain University, Khartoum, Sudan.
Ali M M EdrisDepartment of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.
Ayman AhmedInstitute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
Rihab A OmerDepartment of Molecular Biology, Institute of Parasitology, University of Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIL-17A G197A and IL-17F A7488G polymorphisms has been identified to be associated with the susceptibility to many diseases. This study aimed to investigate the frequency distribution of IL-17A G197A and IL-17F A7488G polymorphisms among healthy Sudanese population. A descriptive cross-sectional hospital-based molecular study conducted in different sites throughout Sudan. Two ml blood samples were collected from 717 healthy participants. Demographic data and the medical history of the participants were collected.

resultsOf the 717 participants, 355 (49.5%) were males and 362 (50.5%) were females, their mean age was 30.2 ± 17.2 and 32.2 ± 16.5, respectively. For IL-17A, the most frequent genotype detected among males and females was IL-17A heterozygote allele (AG); 215 (60.6%) and 194 (53.6%), respectively. Whereas, for IL-17F, the most frequent allele among males and females was the homozygote allele (AA); 298 (83.9%) for males and 322 (89.0%) for females. HWE for genotype distributions of IL-17A was showing statistical insignificance for IL-17A among males and females, P value 0.614. While HWE for IL-17F reached the equilibrium level, P value 0.048. The most frequent age group was those aged between 21 to 40 years; 281 (39.2%). Arab constituted the major ethnicity of the study participants; 418 (58.3%), P value 0.034.

Indexed as

Polymorphism, GeneticAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCross-Sectional StudiesFemaleGene FrequencyGenotypeHumansInfantInterleukin-17MaleMiddle AgedIL17A protein, humanIL17F protein, humanInterleukin-17Healthy populationInterleukin 17AInterleukin 17FPolymorphismSudan

Identifiers

PMID32616024
PMCPMC7330939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.