ArticleBMC infectious diseases2020
Epidemiology and genetic diversity of circulating dengue viruses in Medellin, Colombia: a fever surveillance study.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Early warning of serotype replacement, spatial risk redistribution, and shifting clinical phenotypes: Insights from the 2023-2025 dengue outbreak in Meta, Colombia.PLoS neglected tropical diseases · 2026Observational
- Dengue virus genetic diversity and lineage dynamics in Thailand: implications for surveillance and vaccine implementation.Virology journal · 2026Article
- Assessing the diagnostic performance of clinical, serological and molecular approaches to improve dengue case detection in the Peruvian Amazon.PLoS neglected tropical diseases · 2026Article
- Effect of Socioeconomic Strata and Land Cover on Dengue Hotspots in Medellin, Colombia.The American journal of tropical medicine and hygiene · 2025Article
- Dengue virus genomic surveillance in the applying Wolbachia to eliminate dengue trial reveals genotypic efficacy and disruption of focal transmission.Scientific reports · 2024Article
- The Spatiotemporal Distribution and Molecular Characterization of Circulating Dengue Virus Serotypes/Genotypes in Senegal from 2019 to 2023.Tropical medicine and infectious disease · 2024Article
- Dengue Burden and Factors Influencing Severity in Honduras: A Descriptive and Analytical Study.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- Characterization of Dengue Virus Serotype 2 Cosmopolitan Genotype Circulating in Colombia.The American journal of tropical medicine and hygiene · 2023Article
- Article
- Multifoci and multiserotypes circulation of dengue virus in Senegal between 2017 and 2018.BMC infectious diseases · 2021Article
- Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018.Viruses · 2021Article
- Spatial and temporal population dynamics of male and female Aedes albopictus at a local scale in Medellín, Colombia.Parasites & vectors · 2021Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundDengue fever is a major public health problem in Colombia. A fever surveillance study was conducted for evaluation of the clinical, epidemiological, and molecular patterns of dengue, prior to Chikungunya and Zika epidemics.
methodsIn November 2011-February 2014, a passive facility-based surveillance was implemented in Santa Cruz Hospital, Medellin, and enrolled eligible febrile patients between 1 and 65 years-of-age. Acute and convalescent blood samples were collected 10-21 days apart and tested for dengue using IgM/IgG ELISA. RNA was extracted for serotyping using RT-PCR on acute samples and genotyping was performed by sequencing.
resultsAmong 537 febrile patients enrolled during the study period, 29% (n = 155) were identified to be dengue-positive. Only 7% of dengue cases were hospitalized, but dengue-positive patients were 2.6 times more likely to be hospitalized, compared to non-dengue cases, based on a logistic regression. From those tested with RT-PCR (n = 173), 17 were dengue-confirmed based on PCR and/or virus isolation showing mostly DENV-3 (n = 9) and DENV-4 (n = 7) with 1 DENV-1. Genotyping results showed that: DENV-1 isolate belongs to the genotype V or American/African genotype; DENV-3 isolates belong to genotype III; and DENV-4 isolates belong to the II genotype and specifically to the IIb sub-genotype or linage.
conclusionsOur surveillance documented considerable dengue burden in Santa Cruz comuna during non-epidemic years, and genetic diversity of circulating DENV isolates, captured prior to Chikungunya epidemic in 2014 and Zika epidemic in 2015. Our study findings underscore the need for continued surveillance and monitoring of dengue and other arboviruses and serve as epidemiological and molecular evidence base for future studies to assess changes in DENV transmission in Medellin, given emerging and re-emerging arboviral diseases in the region.
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