Evidence map›Paper›PMID 32615982›Full record

ArticleLipids in health and disease2020

Association between atherogenic index of plasma and coronary artery calcification progression in Korean adults.

Ji Sun Nam, Min Kyung Kim, Joo Young Nam, Kahui Park, Shinae Kang, Chul Woo Ahn, Jong Suk Park

Open access · goldAbstract read
In one paragraph

Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ji Sun NamDivision of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Min Kyung KimDivision of Endocrinology, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea.
Joo Young NamDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, South Korea.
Kahui ParkDivision of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Shinae KangDivision of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Chul Woo AhnDivision of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Jong Suk ParkDivision of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea. pjs00@yuhs.ac.
Yonsei University · KRNational Health Insurance Service Ilsan Hospital · KRHallym University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDyslipidemia is a well-known risk factor for cardiovascular disease (CVD). Recently, atherogenic index of plasma (AIP) has been proposed as a novel predictive marker for CVD, and few cross sectional studies have demonstrated a relationship between AIP and coronary artery disease. The present study investigated the association between AIP and the progression of coronary artery calcification (CAC) in Korean adults without CVD.

methodsA total of 1124 participants who had undergone CAC measurement at least twice by multi-detector computed tomography (CT) at a health check-up center were enrolled. Their anthropometric measurements and various cardiovascular risk factors were assessed. AIP was defined as the base 10 logarithm of the ratio of the concentration of triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C). CAC progression was defined as either incident CAC in a CAC-free population at baseline, or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACS) in subjects with detectable CAC at baseline.

resultsCAC progression was observed in 290 subjects (25.8%) during the mean follow-up of 4.2 years. All subjects were stratified into three groups according to AIP. There were significant differences in cardiovascular parameters among groups at baseline. The follow-up CAC and the incidence of CAC progression increased gradually with rising AIP tertiles. In logistic regression analysis, the odds ratio for CAC progression was 2.27 when comparing the highest to the lowest tertile of AIP (95% CI: 1.61-3.19; P for trend < 0.01). However, this association was attenuated after adjustment for multiple risk factors (P for trend = 0.67).

conclusionsThere is a significant correlation between AIP and the progression of CAC in subjects without CVD. Although AIP was not an independent predictor of CAC progression, AIP should be considered when estimating the current as well as future CVD risk, along with other traditional risk factors.

Indexed as

Asian PeopleAtherosclerosisBiomarkersCalcinosisCholesterol, HDLCoronary Artery DiseaseFemaleHumansLongitudinal StudiesMaleMiddle AgedMultidetector Computed TomographyRetrospective StudiesTriglyceridesBiomarkersCholesterol, HDLTriglyceridesAtherogenic index of plasmaAtherosclerosisCardiac computed tomographyCardiovascular risk factorCoronary artery calcification progressionCoronary artery calcification score

Identifiers

PMID32615982
PMCPMC7331149
OpenAlexW3039797328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.