Evidence map›Paper›PMID 32615887›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline.

Kelsey R Thomas, Jessica R Osuna, Alexandra J Weigand, Emily C Edmonds, Alexandra L Clark, Sophia Holmqvist, Isabel H Cota, Christina E Wierenga, Mark W Bondi, Katherine J Bangen and 1 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 59 citations in OpenAlex.

  1. A phase 2A/B randomized trial of metabolic modulators intranasal insulin and empagliflozin for MCI and early AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  2. Article
  3. Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: A pilot single-arm trial.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  4. Article
  5. Neuropsychiatric symptom phenotypes for early detection of risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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  12. Review
  13. Associations of Post-Traumatic Stress Disorder and Objective Subtle Cognitive Difficulties in Cognitively Unimpaired Older Veterans.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
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  20. Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kelsey R ThomasResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.ORCID 0000-0003-4277-8876
Jessica R OsunaResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Alexandra J WeigandResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Emily C EdmondsResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Alexandra L ClarkResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Sophia HolmqvistResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Isabel H CotaResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Christina E WierengaResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Mark W BondiDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Katherine J BangenResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Alzheimer’s Disease Neuroimaging Initiative
University of California San Diego · USVA San Diego Healthcare System · USSan Diego State University · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
New Quantitative Neuroimaging Metrics of Structural and Functional Connectivity of the Locus Coeruleus as a Novel Biomarker of Alzheimer's Disease Pathogenesis and ProgressionR01AG054049 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, FRANK, LAWRENCE R · 2017 to 2021
$4.1M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
Identifying best methods for the detection of subtle cognitive declineR03AG070435 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMAS, KELSEY R · 2021 to 2022
$316k
Cognitive and Brain Changes in Preclinical Alzheimer's DiseaseI01CX000565 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WIERENGA, CHRISTINA E · 2013 to 2022
–
Impact of Diabetes on Cognitive and Perfusion Inefficiencies in Preclinical ADIK2CX001865 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI Kelsey R Thomas · 2020 to 2026
–
Cerebral arterial compliance, blood flow, and cognition in Veterans with diabetesI01CX001842 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BANGEN, KATHERINE · 2020 to 2023
–
Neuroimaging and Vascular Correlates of Mild Cognitive Impairment SubtypesIK2CX000938 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BANGEN, KATHERINE · 2015 to 2019
–
Cognitive and Biomarker Profiles of Accurate and Inaccurate MCI DiagnosisIK2CX001415 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI EDMONDS, EMILY CHARLOTTE · 2017 to 2021
–
CSRD VA I01 CX000565CSRD VA I01 CX001842CSRD VA IK2 CX000938CSRD VA IK2 CX001415CSRD VA IK2 CX001865NIA NIH HHS R01 AG049810NIA NIH HHS R01 AG054049NIA NIH HHS R03 AG070435NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Although cerebral blood flow (CBF) alterations are associated with Alzheimer's disease (AD), CBF patterns across prodromal stages of AD remain unclear. Therefore, we investigated patterns of regional CBF in 162 Alzheimer's Disease Neuroimaging Initiative participants characterized as cognitively unimpaired (CU;

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBrainCerebrovascular CirculationCognitive DysfunctionCross-Sectional StudiesEarly DiagnosisFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingNeuropsychological TestsAlzheimer’s diseasecerebral blood flowearly detectionmild cognitive impairmentsubtle cognitive decline

Identifiers

PMID32615887
PMCPMC8054731
OpenAlexW3039890225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.