Evidence map›Paper›PMID 32615727›Full record

Trial reportEndocrinology and metabolism (Seoul, Korea)2020

Effect of Lactobacillus sakei, a Probiotic Derived from Kimchi, on Body Fat in Koreans with Obesity: A Randomized Controlled Study.

Soo Lim, Ji Hye Moon, Chol Min Shin, Dahye Jeong, Bongjoon Kim

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Endocrinology and metabolism (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03248414 (Investigation of Anti-obesity Properties of Lactobacillus Sakei in Obese Human Subjects), which is not on this map. Cited by 37 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 8 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03248414 nacompletednot on this map

Investigation of Anti-obesity Properties of Lactobacillus Sakei in Obese Human Subjects

TypeinterventionalSponsorSeoul National University Bundang HospitalRan2016 to 2018Enrolled114ConditionsObesityArmsLactobacillus sakei
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 8 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. ProbioticNarra J · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Roles of the gut microbiome in weight management.Nature reviews. Microbiology · 2023
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Efficacy ofNutrients · 2024
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Efficacy and Safety ofFrontiers in endocrinology · 2021
    Trial
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Soo LimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Ji Hye MoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Chol Min ShinDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Dahye JeongCJ Foods R&D, CJ CheilJedang Corporation, Suwon, Korea.
Bongjoon KimCJ CheilJedang Corporation, Suwon, Korea.
Seoul National University Bundang Hospital · KRCJ CheilJedang (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increased prevalence of obesity has led to increases in the prevalence of chronic diseases worldwide. There is interest whether probiotics have an effect on obesity, but the effectiveness and safety of only a few probiotics for the treatment of obesity have been reported. The purpose of this study was to investigate whether ingestion of Lactobacillus sakei (CJLS03) derived from kimchi causes weight loss in people with obesity.

methodsThis randomized, double-blind, placebo-controlled, clinical trial involved 114 adults with a body mass index (BMI) ≥25 kg/m2 who were assigned randomly to a CJLS03 or placebo group. The groups received two allocations of either 5×109 colony-forming units of CJLS03/allocation or the equivalent vehicle for 12 weeks. Demographic and biochemical parameters, and body composition including fat and muscle mass were measured at baseline and after 12 weeks. Changes in body fat, weight, and waist circumference were compared between the two treatment groups. Adverse events were monitored during study period.

resultsBody fat mass decreased by 0.2 kg in the CJLS03 group and increased by 0.6 kg in the placebo group (0.8 kg difference, P=0.018). After the 12 weeks, waist circumference was 0.8 cm smaller in the CJLS03 group than in the placebo group (P=0.013). BMI and body weight did not change after the 12 weeks. Adverse events were mild and did not differ between the two groups.

conclusionThese data suggest that L. sakei (CJLS03) might help people with obesity reduce body fat mass without serious side effects (ClinicalTrials.gov: NCT03248414).

Indexed as

Adipose TissueBody CompositionBody Mass IndexWeight LossAdultAgedBody WeightDouble-Blind MethodFemaleFollow-Up StudiesHumansLatilactobacillus sakeiMaleMiddle AgedObesityProbioticsBody fatLactobacillus sakeiObesityProbiotics

Identifiers

PMID32615727
PMCPMC7386112
OpenAlexW3037510675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.