ArticleEndocrinology and metabolism (Seoul, Korea)2020
Consistency of the Glycation Gap with the Hemoglobin Glycation Index Derived from a Continuous Glucose Monitoring System.
Article in Endocrinology and metabolism (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Hemoglobin glycation index, calculated from a single fasting glucose value, as a prediction tool for severe hypoglycemia and major adverse cardiovascular events in DEVOTE.BMJ open diabetes research & care · 2021Trial
- Increased HbA1c relative to actual glycemic control in patients treated with sodium-glucose cotransporter 2 inhibitors.Journal of diabetes investigation · 2026Article
- Associations of Hemoglobin Glycation Index with Glucose Variability and Time in Ranges in Patients with Type 2 Diabetes Undergoing Continuous Glucose Monitoring.International journal of medical sciences · 2026Article
- Association of Hemoglobin Glycation Index With All-Cause Mortality, Cardiac Mortality, and Cardiovascular Mortality in the General Population: A Retrospective Cohort Study of NHANES Data.Reviews in cardiovascular medicine · 2025Article
- Effect of glycemic gap on prognosis and complications in vulnerable period of acute heart failure.Journal of medical biochemistry · 2025Article
- Deciphering the Association: Critical HDL-C Levels and Their Impact on the Glycation Gap in People Living with HIV.International journal of molecular sciences · 2025Article
- Factors associated with hemoglobin glycation index in adults with type 1 diabetes mellitus: The FGM-Japan study.Journal of diabetes investigation · 2023Article
- Comparative prognostic value of hemoglobin glycation index and glycation gap for mortality risk in adults: A population-based study.Diabetes & vascular disease researchArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiscordances between glycated hemoglobin (HbA1c) levels and glycemic control are common in clinical practice. We aimed to investigate the consistency of the glycation gap with the hemoglobin glycation index (HGI).
methodsFrom 2016 to 2019, 36 patients with type 2 diabetes were enrolled. HbA1c, glycated albumin (GA), and fasting blood glucose levels were simultaneously measured and 72-hour continuous glucose monitoring (CGM) was performed on the same day. Repeated tests were performed at baseline and 1 month later, without changing patients' diabetes management. The HGI was calculated as the difference between the measured HbA1c and the predicted HbA1c that was derived from CGM. The glycation gap was calculated as the difference between the measured and GA-based predicted HbA1c levels.
resultsStrong correlations were found between the mean blood glucose (MBG)-based HGI and the prebreakfast glucose-based HGI (r=0.867, P<0.001) and between the glycation gap and the MBG-based HGI (r=0.810, P<0.001). A close correlation was found between the MBG-based HGI at baseline and that after 1 month (r=0.729, P<0.001), with a y-intercept of 0 and a positive slope.
conclusionThe HGI and glycation gap were highly reproducible, and the magnitudes of repeated determinations were closely correlated. Patients with similar mean glucose levels may have significantly different HbA1c levels.
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