Evidence map›Paper›PMID 32615504›Full record

ArticleMultiple sclerosis and related disorders2020

Sex-specific differences in rim appearance of multiple sclerosis lesions on quantitative susceptibility mapping.

Tolaymat B, Zheng W, Chen H, Choi S, Li X, Harrison Dm

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  11. The X factor in neurodegeneration.The Journal of experimental medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tolaymat BUniversity of Maryland School of Medicine, Baltimore, MD, United States.
Zheng WDepartment of Neurology, Greater Baltimore Medical Center, Baltimore, MD, United States.
Chen HUniversity of Maryland School of Medicine, Baltimore, MD, United States.
Choi SUniversity of Maryland School of Medicine, Baltimore, MD, United States.
Li XF. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Harrison DmUniversity of Maryland School of Medicine, Baltimore, MD, United States; Department of Neurology Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3(rd) Floor, Baltimore, Maryland 201201. Electronic address: dharrison@som.umaryland.edu.
University of Maryland, Baltimore · USGreater Baltimore Medical Center · USKennedy Krieger Institute · US

Funding

In vivo assessment of meningeal inflammation and its clinical impact in multiple sclerosis by 7 Tesla MRIR01NS104403 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRISON, DANIEL M · 2018 to 2022
$3.1M
Grey Matter of Lesions and Neurodegeration in Multiple Sclerosis on 7-Telsa MRIK23NS072366 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRISON, DANIEL M · 2013 to 2017
$928k
NINDS NIH HHS K23 NS072366NINDS NIH HHS L30 NS088825NINDS NIH HHS R01 NS104403
6 · The paper itself

Abstract

backgroundSusceptibility MRI techniques, such as phase and quantitative susceptibility mapping (QSM) reveal lesion heterogeneity in MS, including the presence of lesions with outer rims suggestive of iron accumulation in macrophages and microglia, indicative of chronic-active inflammatory white matter lesions (WMLs).

objectiveTo evaluate the in vivo relationship between chronic-active WMLs (as visualized by rimmed lesions on QSM) and several clinical metrics.

methods39 patients (15 men, 24 women) with MS underwent 7 Tesla brain MRIs and clinical evaluation. Contrast patterns of lesions identified on FLAIR and quantitative susceptibility maps were reviewed and compared to demographic characteristics and disability scores.

results1279 lesions were identified on FLAIR MRI; 846 (66.2%) of these were visible on QSM, 119 (14.1%) of which had visible rims. Lesions visible on QSM were more likely to have rims in men (16.1%, vs 4.9% in women, p=0.009). In a logistic regression model accounting for several factors, male sex conferred a >10-fold risk of having ≥1 rimmed lesion(s) (p=0.026).

conclusionOur findings provide in vivo support for the body of histopathologic literature indicating sex-specific differences in MS WML formation and suggest that QSM can be used to study these sex differences in the future.

Indexed as

Multiple SclerosisBrainFemaleHumansMagnetic Resonance ImagingMaleMicrogliaSex CharacteristicsDisability, SexMagnetic resonance imagingMultiple sclerosisQuantitative susceptibility mappingRim

Identifiers

PMID32615504
PMCPMC7606497
OpenAlexW3036980322

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.