Evidence map›Paper›PMID 32615360›Full record

ReviewCurrent opinion in virology2020

Structural and dynamic asymmetry in icosahedrally symmetric virus capsids.

Asis K Jana, Eric R May

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Asis K JanaDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.
Eric R MayDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA. Electronic address: eric.may@uconn.edu.

Funding

Structural Dynamics of Viral Proteins: Development and Application of Multiscale Computational Methods for Studying Viral Capsids, Proteins and Membrane SystemsR35GM119762 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI Eric Robert May · 2016 to 2026
$4.1M
NIGMS NIH HHS R35 GM119762
6 · The paper itself

Abstract

A common characteristic of virus capsids is icosahedral symmetry, yet these highly symmetric structures can display asymmetric features within their virions and undergo asymmetric dynamics. The fields of structural and computational biology have entered a new realm in the investigation of virus infection mechanisms, with the ability to observe symmetry-breaking features. This review will cover important studies on icosahedral virus structure and dynamics, covering both symmetric and asymmetric conformational changes. However, the main emphasis of the review will be towards recent studies employing cryo-electron microscopy or molecular dynamics simulations, which can uncover asymmetric aspects of these systems relevant to understanding viral physical-chemical properties and their biological impact.

Indexed as

Molecular Dynamics SimulationCapsidCapsid ProteinsComputational BiologyCryoelectron MicroscopyDrug DiscoveryVirionCapsid Proteins

Identifiers

PMID32615360
PMCPMC7746594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.