Evidence map›Paper›PMID 32615138›Full record

ArticleExperimental neurology2020

Improvement of lower urinary tract function by a selective serotonin 5-HT

Ching-Yi Lin, Alexander Sparks, Yu-Shang Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Long-Term 5-HTInternational journal of molecular sciences · 2024
    Article
  5. Review
  6. Upregulated 5-HTJournal of neurotrauma · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ching-Yi LinDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Alexander SparksDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Yu-Shang LeeDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: leey2@ccf.org.
Cleveland Clinic Lerner College of Medicine · US

Funding

Recovery of Bladder Reflexes and Nerve Regeneration after Spinal Cord InjuryR01NS069765 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI LEE, YU-SHANG · 2010 to 2019
$3.1M
NINDS NIH HHS R01 NS069765
6 · The paper itself

Abstract

Spinal cord injury (SCI) above the lumbosacral level results in lower urinary tract dysfunction, including (1) detrusor hyperreflexia, wherein bladder compliance is low, and (2) a lack of external urethral sphincter (EUS) control, leading to detrusor-sphincter dyssynergia (DSD) with poor voiding efficiency. Experimental studies in animals have shown a dense innervation of serotonergic (5-HT) fibers and multiple 5-HT receptors in the spinal reflex circuits that control voiding function. Here, we investigated the efficacy of NLX-112 (a.k.a. befiradol or F13640), in regulating lower urinary tract function after T8 contusive SCI in rats. NLX-112 is a very potent, highly-selective, and fully efficacious 5-HT

Indexed as

AnimalsDose-Response Relationship, DrugElectromyographyFemalePiperidinesPyridinesRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsSpinal Cord InjuriesUrethraUrinary Bladder DiseasesUrinary Bladder, NeurogenicUrinary Bladder, OveractiveUrinary TractbefiradolPiperidinesPyridinesReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor Agonists5-HT(1A) receptor agonistBladderExternal urethral sphincterSpinal cord injury

Identifiers

PMID32615138
PMCPMC7416759
OpenAlexW3038641398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.