Evidence map›Paper›PMID 32615087›Full record

ArticleCell2020

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.

Phi T Nguyen, Leah C Dorman, Simon Pan, Ilia D Vainchtein, Rafael T Han, Hiromi Nakao-Inoue, Sunrae E Taloma, Jerika J Barron, Ari B Molofsky, Mazen A Kheirbek and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 386 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
386citing papers in PubMed, 1 pooled it
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

386 citing papers in PubMed, 1 synthesis or guideline pooled it, 602 citations in OpenAlex.

  1. Pooled it
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  18. The neuroimmune system and cognition.Nature immunology · 2026
    Review
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326 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Phi T NguyenDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Leah C DormanDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Simon PanDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Ilia D VainchteinDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Rafael T HanDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Hiromi Nakao-InoueDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Sunrae E TalomaDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Jerika J BarronDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Ari B MolofskyDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Mazen A KheirbekDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Anna V MolofskyDepartment of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA. Electronic address: anna.molofsky@ucsf.edu.
University of California, San Francisco · US

Funding

Hippocampal modulation of subcortical circuits in the control of emotional behaviorR01MH108623 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mazen A Kheirbek · 2016 to 2026
$6.0M
Microglial remodeling of the extracellular matrix in memory circuitsR01MH125000 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2021 to 2025
$3.3M
Coordinate regulation of neural circuit remodeling by glia: a prospective molecular approachDP2MH116507 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2017 to 2017
$2.4M
How is anxiety-related information relayed across hippocampal-prefrontal circuitsR01MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2019 to 2022
$2.3M
Astrocyte-microglial communication in developmental synapse formationR01MH119349 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ANNA V · 2019 to 2023
$2.0M
Circuit and cellular mechanisms of adult neurogenesis in context encoding and discriminationR01MH111754 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A · 2017 to 2021
$2.0M
NIMH NIH HHS DP2 MH116507NIMH NIH HHS R01 MH108623NIMH NIH HHS R01 MH111754NIMH NIH HHS R01 MH117961NIMH NIH HHS R01 MH119349NIMH NIH HHS R01 MH125000
6 · The paper itself

Abstract

Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. We find that the cytokine interleukin-33 (IL-33) is expressed by adult hippocampal neurons in an experience-dependent manner and defines a neuronal subset primed for synaptic plasticity. Loss of neuronal IL-33 or the microglial IL-33 receptor leads to impaired spine plasticity, reduced newborn neuron integration, and diminished precision of remote fear memories. Memory precision and neuronal IL-33 are decreased in aged mice, and IL-33 gain of function mitigates age-related decreases in spine plasticity. We find that neuronal IL-33 instructs microglial engulfment of the extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accumulation of ECM proteins in contact with synapses. These data define a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

Indexed as

AgingAnimalsExtracellular MatrixFearGene Expression RegulationHippocampusInterleukin-1 Receptor-Like 1 ProteinInterleukin-33MemoryMiceMice, Inbred C57BLMice, TransgenicMicrogliaNeuronal PlasticityNeuronsSignal TransductionInterleukin-1 Receptor-Like 1 ProteinInterleukin-33microglia, hippocampus, extracellular matrix, aging, memory, dendrite remodeling, interleukin-33

Identifiers

PMID32615087
PMCPMC7497728
OpenAlexW3039508055

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.