Evidence map›Paper›PMID 32615040›Full record

ArticleThe Journal of organic chemistry2020

Development of a Convergent Enantioselective Synthetic Route to (-)-Myrocin G.

Martin Tomanik, Christos Economou, Madeline C Frischling, Mengzhao Xue, Victoria A Marks, Brandon Q Mercado, Seth B Herzon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Martin TomanikDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Christos EconomouDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Madeline C FrischlingDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Mengzhao XueDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Victoria A MarksDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Brandon Q MercadoDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Seth B HerzonDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-5940-9853

Funding

Synthetic and translational studies of antitumor and antimicrobial natural products.R35GM131913 · NIGMS · YALE UNIVERSITY · PI Seth B. Herzon · 2019 to 2026
$4.7M
Synthetic and Mechanistic Studies of Myrocin Antitumor AgentsF31CA213964 · NCI · YALE UNIVERSITY · PI ECONOMOU, CHRISTOS · 2017 to 2018
$74k
NCI NIH HHS F31 CA213964NIGMS NIH HHS R35 GM131913
6 · The paper itself

Abstract

Myrocins are a family of antiproliferative antibiotic fungal metabolites possessing a masked electrophilic cyclopropane. Preliminary chemical reactivity studies imputed the bioactivity of these natural products to a DNA cross-linking mechanism, but this hypothesis was not confirmed by studies with native DNA. We recently reported a total synthesis of (-)-myrocin G (

Indexed as

Biological ProductsLactonesDNAFungiStereoisomerismBiological ProductsDNALactones

Identifiers

PMID32615040
PMCPMC7520802

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.