Evidence map›Paper›PMID 32614937›Full record

ArticleJACC. Basic to translational science2020

Cardiac BIN1 Replacement Therapy Ameliorates Inotropy and Lusitropy in Heart Failure by Regulating Calcium Handling.

Jessica Gambardella, Xu Jun Wang, John Ferrara, Marco Bruno Morelli, Gaetano Santulli

Open access · goldAbstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Role of Dyadic Proteins in Proper Heart Function and Disease.International journal of molecular sciences · 2025
    Review
  3. [Association between serum BIN1 level and Killip class in patients with acute myocardial infraction].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Jessica GambardellaDepartment of Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, New York.
Xu Jun WangDepartment of Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, New York.
John FerraraDepartment of Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, New York.
Marco Bruno MorelliDepartment of Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, New York.
Gaetano SantulliDepartment of Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, New York.
Albert Einstein College of Medicine · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
REGULATION OF THE INSULIN RECEPTOR KINASER01DK033823 · NIDDK · UNIVERSITY OF IOWA · PI KURLAND, IRWIN JACK, PESSIN, JEFFREY E. · 1986 to 2022
$6.7M
Functional role of IP3 receptors in the regulation of cardiac myofibroblastsR01HL146691 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2019 to 2023
$2.1M
Beta Cell Intracellular Calcium and DiabetesR01DK123259 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SANTULLI, GAETANO · 2020 to 2023
$1.7M
Targeting intracellular calcium leak as novel therapy for diabetesR00DK107895 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SANTULLI, GAETANO · 2018 to 2020
$741k
NHLBI NIH HHS R01 HL146691NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R00 DK107895NIDDK NIH HHS R01 DK033823NIDDK NIH HHS R01 DK123259
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

arrhythmiascalcium handlingcBIN1diastolic dysfunctiondyadsheart failureHFpEFpressure overloadRyRsympathetic overdrivet-tubule

Identifiers

PMID32614937
PMCPMC7315227
OpenAlexW3036187184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.