SynthesisPloS one2020
Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Impact of amino acid supplementation on cardiovascular and chronic kidney diseases: a systematic review.Cardiovascular research · 2026Pooled it
- Creatine and Cognition in Aging: A Systematic Review of Evidence in Older Adults.Nutrition reviews · 2026Pooled it
- Impact of team-based primary care on health care utilization among patients with mental and substance use disorders: a systematic review of English-language articles.Family practice · 2025Pooled it
- Does interval time between pulsed dye laser treatments for port-wine stains influence outcome? A systematic review and meta-analysis.Lasers in medical science · 2021Pooled it
- Treatment Outcome Measurement Instruments for Port Wine Stains: A Systematic Review of Their Measurement Properties.Dermatology (Basel, Switzerland) · 2021Pooled it
- Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review.PloS one · 2020Pooled it
- Semi-automated erythema quantification in infantile haemangioma receiving propranolol: a pilot feasibility study.Pediatric surgery international · 2026Article
- Article
- Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations.bioRxiv : the preprint server for biology · 2025Article
- Efficacy and prognostic factors for successful treatment of port-wine stains by 577-nm yellow laser: a cohort study on 42 patients.Lasers in medical science · 2025Article
- Review
- Current clinical evidence is insufficient to support HMME-PDT as the first choice of treatment for young children with port wine birthmarks.Lasers in surgery and medicine · 2024Review
- Patient-Reported Outcomes of Medical Tattooing for Capillary Malformations.Dermatology (Basel, Switzerland) · 2023Article
- Hematoporphyrin Monomethyl Ether Photodynamic Therapy of Port Wine Stain: Narrative Review.Clinical, cosmetic and investigational dermatology · 2023Review
- Three-dimensional image-guided topical photodynamic therapy system with light dosimetry dynamic planning and monitoring.Biomedical optics express · 2023Article
- A core outcome domain set for clinical research on capillary malformations (the COSCAM project): an e-Delphi process and consensus meeting.The British journal of dermatology · 2022Article
- Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains: Multivariate Analysis of Clinical Efficacy and Optical Coherence Tomography Appearance.Frontiers in medicine · 2022Article
- Development of a core outcome domain set for clinical research on capillary malformations (the COSCAM project).Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
- Correction: Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review.PloS one · 2020Article
- Port wine stain treatment outcomes have not improved over the past three decades.Journal of the European Academy of Dermatology and Venereology : JEADV · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundValid and reliable outcome measures are needed to determine and compare treatment results of port wine stain (PWS) studies. Besides, uniformity in outcome measures is crucial to enable inter-study comparisons and meta-analyses. This study aimed to assess the heterogeneity in reported PWS outcome measures by mapping the (clinical) outcome measures currently used in prospective PWS studies.
methodsOVID MEDLINE, OVID Embase, and CENTRAL were searched for prospective PWS studies published from 2005 to May 2020. Interventional studies with a clinical efficacy assessment were included. Two reviewers independently evaluated methodological quality using a modified Downs and Black checklist.
resultsIn total, 85 studies comprising 3,310 patients were included in which 94 clinician/observer-reported clinical efficacy assessments had been performed using 46 different scoring systems. Eighty-one- studies employed a global assessment of PWS appearance/improvement, of which -82% was expressed as percentage improvement and categorized in 26 different scoring systems. A wide variety of other global and multi-item scoring systems was identified. As a result of outcome heterogeneity and insufficient data reporting, only 44% of studies could be directly compared. A minority of studies included patient-reported or objective outcomes. Thirteen studies of good quality were found.
conclusionClinical PWS outcomes are highly heterogeneous, which hampers study comparisons and meta-analyses. Consensus-based development of a core outcome-set would benefit future research and clinical practice, especially considering the lack of high-quality trials.
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