ArticlePloS one2020
History of breastfeeding but not mode of delivery shapes the gut microbiome in childhood.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- The root rhizosphere as a functional analog to the gut microbiome: Cases for microbial symbiosis and dysbiosis in parallel contexts.PNAS nexus · 2026Review
- Antibiotic and healthcare exposure impact on dynamics of third-generation cephalosporin-resistant Enterobacterales colonisation in Cambodian children: a six-month cohort study.Antimicrobial resistance and infection control · 2026Article
- Seeding and feeding: nutrition and birth-associated exposures shape gut microbiome assembly in breastfed infants.Gut microbes · 2025Article
- Interactions with alloparents are associated with the diversity of infant skin and fecal bacterial communities in Chicago, United States.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Characterization of middle ear microbiome in otitis media with effusion in Hungarian children:Heliyon · 2024Article
- Social environment influences microbiota and potentially pathogenic bacterial communities on the skin of developing birds.Animal microbiome · 2024Article
- Association between breast feeding and food consumption according to the degree of processing in Brazil: a cohort study.BMJ open · 2024Article
- Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome.Microorganisms · 2024Article
- Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia.Scientific reports · 2024Article
- Evaluating the association between caesarean delivery and weight status in early childhood in a Japanese birth cohort study.Scientific reports · 2023Article
- Early Colonization of the Intestinal Microbiome of Neonatal Piglets Is Influenced by the Maternal Microbiome.Animals : an open access journal from MDPI · 2023Article
- Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age.PLoS biology · 2023Article
- Associations of Childhood and Perinatal Blood Metals with Children's Gut Microbiomes in a Canadian Gestation Cohort.Environmental health perspectives · 2022Article
- Mother's Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis.Nutrients · 2021Article
- Host specificity of the gut microbiome.Nature reviews. Microbiology · 2021Review
- Early-Life Development of the Bifidobacterial Community in the Infant Gut.International journal of molecular sciences · 2021Article
- Bacterial Gut Microbiota and Infections During Early Childhood.Frontiers in microbiology · 2021Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe naïve neonatal gut is sensitive to early life experiences. Events during this critical developmental window may have life-long impacts on the gut microbiota. Two experiences that have been associated with variation in the gut microbiome in infancy are mode of delivery and feeding practices (eg, breastfeeding). It remains unclear whether these early experiences are responsible for microbial differences beyond toddlerhood.
aimsOur study examined whether mode of delivery and infant feeding practices are associated with differences in the child and adolescent microbiome. DESIGN, SUBJECTS, MEASURES: We used an adoption-sibling design to compare genetically related siblings who were reared together or apart. Gut microbiome samples were collected from 73 children (M = 11 years, SD = 3 years, range = 3-18 years). Parents reported on child breastfeeding history, age, sex, height, and weight. Mode of delivery was collected through medical records and phone interviews.
resultsNegative binomial mixed effects models were used to identify whether mode of delivery and feeding practices were related to differences in phylum and genus-level abundance of bacteria found in the gut of child participants. Covariates included age, sex, and body mass index. Genetic relatedness and rearing environment were accounted for as random effects. We observed a significant association between lack of breastfeeding during infancy and a greater number of the genus Bacteroides in stool in childhood and adolescence.
conclusionThe absence of breastfeeding may impart lasting effects on the gut microbiome well into childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.