ArticlePLoS biology2020
Resting-state brain and spinal cord networks in humans are functionally integrated.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain MRI changes in degenerative cervical myelopathy: a systematic review.EBioMedicine · 2024Pooled it
- The Motor Engram of Functional Connectivity Generated by Acute Whole-Body Dynamic Balance Training.Medicine and science in sports and exercise · 2022Trial
- Spinal cord structural and functional architecture and its shared organization with the brain across the adult lifespan.Nature communications · 2026Article
- Neptune: a toolbox for spinal cord functional MRI data processing and quality assurance.bioRxiv : the preprint server for biology · 2026Article
- Medullary and C3-C4 propriospinal pathways underlying mammalian forelimb movement control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A corticospinal signature for interindividual pain sensitivity.Nature communications · 2025Article
- Simultaneous zero echo time fMRI of rat brain and spinal cord.Magnetic resonance in medicine · 2025Article
- CoSpine open access simultaneous cortico-spinal fMRI database of thermal pain and motor tasks.Scientific data · 2025Article
- Differential encoding of noxious heat and self-reported pain along corticospinal networks: a simultaneous spinal cord-brain fMRI study.bioRxiv : the preprint server for biology · 2025Article
- Mapping Human Proprioceptive Projections of Upper Limb Muscles Through Spinal Cord fMRI.Human brain mapping · 2025Article
- Simultaneous zero echo time fMRI of rat brain and spinal cord.bioRxiv : the preprint server for biology · 2025Article
- Prior knowledge changes initial sensory processing in the human spinal cord.Science advances · 2025Article
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
- Changes in functional connectivity in relapsing-remitting multiple sclerosis spinal cord measured via region-based and data-driven analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Influence of scanning plane on Human Spinal Cord functional Magnetic Resonance echo planar imaging.PloS one · 2025Article
- Integrating brainstem and cortical functional architectures.Nature neuroscience · 2024Article
- A multichannel electrophysiological approach to noninvasively and precisely record human spinal cord activity.PLoS biology · 2024Article
- Toward a brighter constellation: multiorgan neuroimaging of neural and vascular dynamics in the spinal cord and brain.Neurophotonics · 2024Article
- Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla.Human brain mapping · 2024Article
- Spinal fMRI demonstrates segmental organisation of functionally connected networks in the cervical spinal cord: A test-retest reliability study.Human brain mapping · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.