Evidence map›Paper›PMID 32614696›Full record

ArticleHuman vaccines & immunotherapeutics2021

Effect of aging on immunogenicity and efficacy of inactivated influenza vaccines in cotton rats

Marina S Boukhvalova, Emma Mortensen, Aissatou Mbaye, Jamall McKay, Jorge C G Blanco

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marina S BoukhvalovaSigmovir Biosystems, Inc ., Rockville, MD, USA.
Emma MortensenSigmovir Biosystems, Inc ., Rockville, MD, USA.
Aissatou MbayeSigmovir Biosystems, Inc ., Rockville, MD, USA.
Jamall McKaySigmovir Biosystems, Inc ., Rockville, MD, USA.
Jorge C G BlancoSigmovir Biosystems, Inc ., Rockville, MD, USA.
Sigmovir Biosystems (United States) · US

Funding

Eritoran (E5564), a TLR4 antagonist, as a novel therapeutic for influenzaR01AI104541 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANCO, JORGE C, VOGEL, STEFANIE N. · 2013 to 2016
$3.4M
Targeting TLR Signaling Pathways to Blunt Pathogen-mediated Acute Lung InjuryR01AI125215 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANCO, JORGE C, VOGEL, STEFANIE N. · 2017 to 2021
$2.7M
6 · The paper itself

Abstract

Inactivated influenza vaccines are known to be less immunogenic in human elderly in regards to serologic antibody response induced by vaccination. Accumulating evidence, however, points to a comparable effectiveness of influenza vaccines in the young and the elderly individuals. In the current study, we assessed immunogenicity and effectiveness of trivalent inactivated vaccine FluLaval in young and aged cotton rats

Indexed as

Influenza, HumanInfluenza VaccinesAgingAnimalsAntibodies, ViralHemagglutination Inhibition TestsSigmodontinaeVaccines, InactivatedAntibodies, ViralInfluenza VaccinesVaccines, Inactivatedagingcotton ratefficacyelderlyimmunogenicityInfluenza vaccinesSigmodon hispidusyoung

Identifiers

PMID32614696
PMCPMC7872023
OpenAlexW3038991618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.