ReviewHuman vaccines & immunotherapeutics2020
The importance of semen leukocytes in HIV-1 transmission and the development of prevention strategies.
Review in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A porcine model of chronic hepatitis E virus (HEV) infection identifies male reproductive glands as sites of viral persistence.Virulence · 2026Article
- Losing Less in Translation: Relating the Preclinical Evidence Base for Active and Passive Immunity to Prevention of HIV-1 Infection in Humans.Journal of medical primatology · 2025Review
- Exogenous Metals Indirectly Affect Human Semen Quality via Immune Cells at Single-Cell Resolution.Environment & health (Washington, D.C.) · 2025Article
- Seminal plasma inhibits Chlamydia trachomatis infection in vitro, and may have consequences on mucosal immunity.Scientific reports · 2024Article
- Update on known and emergent viruses affecting human male genital tract and fertility.Basic and clinical andrology · 2024Review
- HIV-Host Cell Interactions.Cells · 2023Review
- Review
- Impact of Caveolin-Mediated Endocytosis on the Trafficking of HIV within the Colonic Barrier.Journal of virology · 2022Article
- Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention.Frontiers in immunology · 2022Review
- Round Cells in Diagnostic Semen Analysis: A Guide for Laboratories and Clinicians.British journal of biomedical science · 2022Review
- Implications of RNA Viruses in the Male Reproductive Tract: An Outlook on SARS-CoV-2.Frontiers in microbiology · 2021Review
- Semen Washing and Intrauterine Insemination for Reducing the Risk of Human Immunodeficiency Virus Transmission in Serodiscordant Couples: A Cross-sectional Study.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
HIV-1 sexual transmission occurs mostly through contaminated semen, which is a complex mixture of soluble factors with immunoregulatory functions and cells. It is well established that semen cells from HIV-1-infected men are able to produce the virus and that are harnessed to efficiently interact with mucosal barriers exposed during sexual intercourse. Several cofactors contribute to semen infectivity and may enhance the risk of HIV-1 transmission to a partner by increasing local HIV-1 replication in the male genital tract, thereby increasing the number of HIV-1-infected cells and the local HIV-1 shedding in semen. The introduction of combination antiretroviral therapy has improved the life expectancy of HIV-1 infected individuals; however, there is evidence that systemic viral suppression does not always reflect full viral suppression in the seminal compartment. This review focus on the role semen leukocytes play in HIV-1 transmission and discusses implications of the increased resistance of cell-mediated transmission to immune-based prevention strategies.
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