Evidence map›Paper›PMID 32614452›Full record

ArticleThe Journal of infectious diseases2021

Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients.

Om Prakash Singh, Genevieve Syn, Susanne Nylén, Christian Engwerda, David Sacks, Mary E Wilson, Rajiv Kumar, Jaya Chakravarty, Shyam Sundar, Jenefer M Blackwell and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Precision Medicine in Control of Visceral Leishmaniasis Caused byFrontiers in cellular and infection microbiology · 2021
    Review
  4. Genetics, Transcriptomics and Meta-Taxonomics in Visceral Leishmaniasis.Frontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 6 countries.

Om Prakash SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Genevieve SynTelethon Kids Institute, The University of Western Australia, Nedlands, Western Australia, Australia.
Susanne NylénDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Christian EngwerdaQIMR Berghofer Medical Research Institute, Brisbane, Australia.
David SacksLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes for Health, Bethesda, Maryland, USA.
Mary E WilsonDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Rajiv KumarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Jaya ChakravartyDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Shyam SundarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Jenefer M BlackwellTelethon Kids Institute, The University of Western Australia, Nedlands, Western Australia, Australia.
Michaela FakiolaDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Institute of Medical Sciences · INBanaras Hindu University · INIstituto Nazionale Genetica Molecolare · ITKarolinska Institutet · SENational Institute of Allergy and Infectious Diseases · USQIMR Berghofer Medical Research Institute · AUThe Kids Research Institute Australia · AUUniversity of Iowa · USUniversity of Western Australia · AU

Funding

IMMUNE REGULATION AND VACCINE DEVELOPMENT IN LEISHMANIASISZIAAI000494 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SACKS, DAVID · 2009 to 2025
$11.8M
Visceral Leishmaniasis in Bihar State, IndiaP50AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2007 to 2016
$6.4M
Visceral Leishmaniasis in Bihar State, IndiaU19AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2017 to 2021
$2.8M
The Role of Exosomes in the Pathogenesis of LeishmaniasisI01BX000536 · VA · IOWA CITY VA MEDICAL CENTER · PI WILSON, MARY E · 2009 to 2023
–
Innate inflammatory cells in leishmaniasisI01BX001983 · VA · IOWA CITY VA MEDICAL CENTER · PI WILSON, MARY E · 2014 to 2022
–
BLRD VA I01 BX000536BLRD VA I01 BX001983NIAID NIH HHS P50 AI074321NIAID NIH HHS U19 AI074321
6 · The paper itself

Abstract

Visceral leishmaniasis (VL; Leishmania donovani) cases produce interferon-γ and tumor necrosis factor in response to soluble leishmanial antigen (SLA) in whole-blood assays. Using transcriptional profiling, we demonstrate the impact of interleukin-10 (IL-10), a cytokine implicated in VL, on this response. SLA stimulation identified 28 differentially expressed genes (DEGs), 17/28 in a single network with TNF as hub. SLA plus anti-IL-10 produced 454 DEGs, 292 in a single network with TNF, IFNG, NFKBIA, IL6, and IL1B as hubs in concert with a remarkable chemokine/cytokine storm. Our data demonstrate the singular effect of IL-10 as a potent immune modulator in VL.

Indexed as

Antibodies, ProtozoanAntigens, ProtozoanCytokinesGene ExpressionHumansInterferon-gammaInterleukin-10Leishmania donovaniLeishmaniasis, VisceralTumor Necrosis Factor-alphaAntibodies, ProtozoanAntigens, ProtozoanCytokinesIL10 protein, humanInterferon-gammaInterleukin-10Tumor Necrosis Factor-alphaanticytokine storminterleukin-10RNA expressionsoluble leishmania antigenvisceral leishmaniasiswhole-blood assays

Identifiers

PMID32614452
PMCPMC7881328
OpenAlexW3038697000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.