ArticlePediatric blood & cancer2020
The association between timely opioid administration and hospitalization in children with sickle cell disease presenting to the emergency department in acute pain.
Article in Pediatric blood & cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Emergency Presentations of Pediatric Sickle Cell Disease in French Guiana.Diseases (Basel, Switzerland) · 2025Article
- Article
- Return visit rates after an emergency department discharge for children with sickle cell pain episodes.Pediatric blood & cancer · 2023Article
- Intranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso-occlusive pain: A multicenter pediatric emergency medicine perspective.American journal of hematology · 2023Article
- Management of fever and acute painful crises in children with sickle cell disease in emergency departments: a tertiary hospital experience.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionThe National Heart, Lung, and Blood Institute guidelines for sickle cell disease (SCD) pain crisis management recommend opioids within 60 minutes of emergency department (ED) registration and every 30 minutes thereafter until acute pain is managed. These guidelines are based on expert opinion without published, supporting data.
objectiveTo evaluate the association between timely ED opioid administration and hospitalization rates in children with SCD.
methodsRetrospective cohort of children presenting to a children's hospital ED with SCD pain between January 1, 2014, and April 30, 2018. Visits were extracted using ICD codes, chief complaints, and receipt of at least one opioid, and then reviewed to confirm the visit was an uncomplicated pain crisis. The primary outcome was hospitalization, yes or no. Generalized estimating equations were used to determine adjusted odds of hospitalization for the timely administration of initial and second doses of opioids.
resultsOf the 902 eligible visits, 368 (40.8%) resulted in hospitalization. The mean (SD) age was 11.9 (± 5.2) years. The first opioid was administered within 60 minutes of arrival in 601 (66.6%) visits. The second opioid was administered within 30 minutes of the first in 84 (12.3%) visits. Receipt of the first opioid within 60 minutes of arrival was not associated with decreased hospitalization (1.30 [0.96-1.76]). However, receipt of the second dose within 30 minutes of the first was associated with decreased hospitalization (0.56 [0.33-0.94]).
conclusionThis study suggests an association between children with SCD receiving a second dose within 30 minutes of the first opioid dose and decreased hospitalizations.
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