ArticleJournal of clinical laboratory analysis2020
Reliability of glycosylated hemoglobin in the diagnosis of gestational diabetes mellitus.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Role of fasting glucose and glycated hemoglobin for gestational diabetes mellitus diagnosis: A prospective study.World journal of diabetes · 2026Article
- NMR-based clinical metabolomics for predictive screening of gestational diabetes mellitus (GDM) during the first trimester: a pilot study on North Indian population.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters.BMC pregnancy and childbirth · 2024Article
- Predelivery HbA1c levels and their relationship with adverse perinatal outcomes in women with normal 75-g OGTT.Archives of gynecology and obstetrics · 2024Observational
- Assessment of Glycemic Control in Patients With Diabetes in Northern Sudan Using Calculated HbA1c.Cureus · 2022Article
- The diagnostic model for early detection of gestational diabetes mellitus and gestational diabetic nephropathy.Journal of clinical laboratory analysis · 2022Article
- The role of first-trimester HbA1c in the early detection of gestational diabetes.BMC pregnancy and childbirth · 2022Article
- Downregulationof circ_0001578 promotes gestational diabetes mellitus by inducing placental inflammationFrontiers in endocrinology · 2022Article
- An age matched case-control study on the risk factors for the gestational diabetes mellitus among primiparous women.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- The diagnostic indicators of gestational diabetes mellitus from second trimester to birth: a systematic review.Clinical diabetes and endocrinology · 2021Review
- The calculated versus the measured glycosylated haemoglobin (HbAJournal of clinical laboratory analysis · 2021Article
- Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring.International journal of environmental research and public health · 2021Article
- Improved gestational diabetes screening protocol.Advances in laboratory medicine · 2021Article
- Reliability of glycosylated hemoglobin in the diagnosis of gestational diabetes mellitus.Journal of clinical laboratory analysis · 2020Article
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5 authors.
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Abstract
backgroundOral glucose tolerance test (OGTT) performed at 24-28 weeks gestation is the current recommended method to the diagnosis of gestational diabetes mellitus (GDM). Many recent studies investigating HbA1c in detecting GDM yield different results. There are no published data on HbA1c in the diagnosis of GDM in Sub-Saharan countries including Sudan.
methodsA cross-sectional study was carried out at the antenatal care of Saad Abuelela Maternity Hospital, Khartoum, Sudan during the period from February to November 2018 to assess the reliability of HbA1c in the diagnosis of GDM. GDM was diagnosed according to the International Association of Diabetes and Pregnancy Study Groups using a 75-g oral glucose tolerance test.
resultsThree hundred and forty-eight women were enrolled. The mean (SD) of the age, gravidity, and gestational age of the enrolled women were 27.8 (5.6) years, 2.36 (2.2) and 26.26 (2.43) weeks, respectively. Sixty-eight women (19.5%) had GDM. A poor productively for HbA1c in diagnosis GDM was shown (AUC = 0.62, 95% CI = 0.55-0.69). At HbA1c level of 4.150%, the sensitivity and specificity of the diagnosis for GDM were 76.51% and 37.85%, respectively. At HbA1c level of 5.850%, the sensitivity and specificity of the diagnosis for GDM were 13.24% and 91.43%, respectively. While there was no significant (Spearman) correlation between fasting blood glucose and HbA1c, there were significant correlations between HbA1c and OGTT 1 and 2 hours of OGTT.
conclusionIn this study, HbA1c has a poor reliability, insufficient sensitivity or specificity for use to diagnose GDM.
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