ArticleJournal of neural engineering2020
On optimal coupling of the 'electronic photoreceptors' into the degenerate retina.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients.Journal of neural engineering · 2026Article
- Amorphous silicon resistors enable smaller pixels in photovoltaic retinal prosthesis.Journal of neural engineering · 2025Article
- Three-dimensional electro-neural interfaces electroplated on subretinal prostheses.Journal of neural engineering · 2024Article
- Losing, preserving, and restoring vision from neurodegeneration in the eye.Current biology : CB · 2023Review
- An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model.Scientific reports · 2023Article
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats.Nature communications · 2022Article
- Photovoltaic implant simulator reveals resolution limits in subretinal prosthesis.Journal of neural engineering · 2022Article
- Pixel size limit of the PRIMA implants: from humans to rodents and back.Journal of neural engineering · 2022Article
- A Comprehensive Review of Methods and Equipment for Aiding Automatic Glaucoma Tracking.Diagnostics (Basel, Switzerland) · 2022Review
- Vertical-junction photodiodes for smaller pixels in retinal prostheses.Journal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Objective: To restore sight in atrophic age-related macular degeneration, the lost photoreceptors can be replaced with electronic implants, which replicate their two major functions: (1) converting light into an electric signal, and (2) transferring visual information to the secondary neurons in the retinal neural network—the bipolar cells (BC). We study the selectivity of BC activation by subretinal implants and dynamics of their response to pulsatile waveforms in order to optimize the electrical stimulation scheme such that retinal signal processing with 'electronic photoreceptors' remains as close to natural as possible. Approach: A multicompartmental model of a BC was implemented to simulate responses of the voltage-gated calcium channels and subsequent synaptic vesicle release under continuous and pulsatile stimuli. We compared the predicted response under various frequencies, pulse durations, and alternating gratings to the corresponding experimental measurements. In addition, electric field was computed for various electrode configurations in a 3-d finite element model to assess the stimulation selectivity via spatial confinement of the field. Main results: The modeled BC-mediated retinal responses were, in general, in good agreement with previously published experimental results. Kinetics of the calcium pumps and of the neurotransmitter release in ribbon synapses, which underpin the BC's temporal filtering and rectifying functions, allow mimicking the natural BC response with high frequency pulsatile stimulation, thereby preserving features of the retinal signal processing, such as flicker fusion, adaptation to static stimuli and non-linear summation of subunits in receptive field. Selectivity of the BC stimulation while avoiding direct activation of the downstream neurons (amacrine and ganglion cells—RGCs) is improved with local return electrodes. Significance: If the retinal neural network is preserved to a large extent in age-related macular degeneration, selective stimulation of BCs with proper spatial and temporal modulation of the extracellular electric field may retain many features of the natural retinal signal processing and hence allow highly functional restoration of sight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.