Evidence map›Paper›PMID 32613576›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2021

Retinal microvascular metrics in untreated essential hypertensives using optical coherence tomography angiography.

Qian Xu, Hongyi Sun, Xin Huang, Yi Qu

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  3. Observational
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  12. Effects of long-term high-altitude exposure on retinal and choroidal microcirculation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  13. Retinal microvasculature and vasoreactivity changes in hypertension using optical coherence tomography-angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Observational
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Qian XuDepartment of Geriatrics, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan, 250012, China.
Hongyi SunDepartment of Geriatrics, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan, 250012, China.
Xin HuangDepartment of Geriatrics, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan, 250012, China.
Yi QuDepartment of Geriatrics, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan, 250012, China. yiqucn@sdu.edu.cn.
Qilu Hospital of Shandong University · CNTaian City Central Hospital · CN

Funding

Tai'an science and technology development plan 2019NS175
6 · The paper itself

Abstract

purposeTo quantify early changes of macular microvascular density, complexity, and peripapillary vessel caliber in hypertension using optical coherence tomography angiography (OCTA).

methodsHypertension (137 eyes) and healthy eyes (79 eyes) as control were involved in this prospective observational study. Indices of the microcirculation included vessel density (VD), skeleton density (SD), vessel diameter index (VDI), fractal dimension (FD) and foveal avascular zone (FAZ) of superficial retinal layer (SRL) and deep retinal layer (DRL), and peripapillary vessel calibers. The correlation of these indices with mean arterial pressure (MAP) and ocular perfusion pressure (OPP) was analyzed.

resultsMean VD of DRL, SD of SRL and DRL, and FD of SRL and DRL were significantly reduced in the macula of hypertensive eyes (all P < 0.01). Meanwhile, hypertensive eyes had margin results of narrower peripapillary arteriolar caliber (P = 0.04). No significant finding was demonstrated on VD of SRL, VDI and FAZ of SRL and DRL, peripapillary total vascular caliber, and peripapillary venal caliber (all P > 0.05). SD and VD of the DRL correlated negatively with MAP (both R = - 0.152, P = 0.03).

conclusionOCTA algorithms may provide an additional inexpensive tool to aid in the preclinical assessment of hypertensive subject.

Indexed as

HypertensionTomography, Optical CoherenceFluorescein AngiographyFundus OculiHumansRetinal VesselsEssential hypertensionOptical coherence tomography angiographyRetinal microvasculatureVessel densityVessel morphology

Identifiers

PMID32613576
OpenAlexW3038381031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.