Evidence map›Paper›PMID 32613555›Full record

SynthesisJournal of molecular neuroscience : MN2020

The Master of Puppets: Pleiotropy of PDGFRB and its Relationship to Multiple Diseases.

Denis A P Moura, João Ricardo Mendes de Oliveira

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of molecular neuroscience : MN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Denis A P MouraLaboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil.
João Ricardo Mendes de OliveiraLaboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil. joao.ricardo@ufpe.br.ORCID http://orcid.org/0000-0001-7474-9266
Universidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The platelet-derived growth factor receptor beta (PDGFRB) gene is involved in proliferative and developmental processes in mammals. Variations in this gene lead to several different syndromic conditions, such as infantile myofibromatosis I, sporadic port-wine stain, primary familial brain calcification, and the Penttinen and overgrowth syndromes. Our objective was to investigate PDGFRB's genetic relationship to clinical conditions and evaluate the protein interactions using GeneNetwork, GeneMANIA, and STRING network databases. We have evidenced the gene's pleiotropy through its many connections and its link to syndromic conditions. Therefore, PDGFRB may be an important therapeutic target for treating such conditions.

Indexed as

Genetic PleiotropyGenetic Predisposition to DiseaseAcro-OsteolysisBinding SitesCalcinosisGrowth DisordersHumansLimb Deformities, CongenitalMyofibromatosisPort-Wine StainProgeriaProtein Interaction MapsReceptor, Platelet-Derived Growth Factor betaPDGFRB protein, humanReceptor, Platelet-Derived Growth Factor betaComplex diseasesMolecular networkPleiotropyVariants

Identifiers

PMID32613555
OpenAlexW3039774197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.