ArticleMetabolomics : Official journal of the Metabolomic Society2020
Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor.
Article in Metabolomics : Official journal of the Metabolomic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Thanatochemistry and the role of hypoxanthine in the post-mortem interval estimation: a systematic literature review.International journal of legal medicine · 2025Pooled it
- Raman mapping on Ag-covered nanostructured substrates as an innovative approach for rapid estimation of post-mortem interval on human whole blood.International journal of legal medicine · 2026Article
- A Step Forward in Post-Mortem Interval Estimation: Multivariate Analysis of Ammonium, Albumin, and Potassium Levels in Vitreous Humor.Diagnostics (Basel, Switzerland) · 2026Article
- Human-to-Rat Validation of PMI Biomarkers: A Bidirectional Cross-Species Metabolomics Study Reveals Asymmetric Translation.Analytical chemistry · 2026Article
- Postmortem Aqueous Humor Analysis in Pigs as an Index of Antemortem Serum Biochemistry Profile and Diagnostic Aid in Animal Welfare.Animals : an open access journal from MDPI · 2026Article
- FTIR Spectroscopy of Vitreous Humor for Postmortem Interval Estimation: A Multivariate Regression Approach.International journal of molecular sciences · 2026Article
- The human metabolome and machine learning improves predictions of the post-mortem interval.Nature communications · 2026Article
- Article
- Recent Advances in Forensic Medicine at the Horizon of Omics Sciences and New Biomarkers for Postmortem Interval Estimation.Maedica · 2025Review
- PMI estimation throughMetabolomics : Official journal of the Metabolomic Society · 2025Article
- Forensic Metabolomics: Enhancing PMI Estimation through Porcine Bone Tissue Profiling.Journal of proteome research · 2025Article
- Cytoprotective Compounds in the Primate Eye: Baseline Metabolomic Profiles ofInternational journal of molecular sciences · 2025Article
- Amino acids and their metabolites as potential biochemical markers in postmortem vitreous humour.International journal of legal medicine · 2025Article
- Estimation of postmortem interval under different ambient temperatures based on multi-organ metabolomics and machine learning algorithm.International journal of legal medicine · 2025Article
- Translating metabolomic evidence gathered from an animal model to a real human scenario: the post-mortem interval issue.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Manner of death prediction: A machine learning approach to classify suicide and non-suicide using blood metabolomics.Forensic science international. Synergy · 2025Article
- Metabolomic biomarkers in vitreous humor: unveiling the molecular landscape of diabetic retinopathy progression.International journal of retina and vitreous · 2025Article
- A fundamental study on postmortem submersion interval estimation by metabolomics analyzing of gastrocnemius muscle from submersed rat models in freshwater.International journal of legal medicine · 2024Article
- An experimental study to estimate the early postmortem interval based on the degradation of lncRNAs in rat brain tissue.Scientific reports · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionApplication of metabolomic methods to forensic studies may expand the limits of the post-mortem interval (PMI) estimation, and improve the accuracy of the estimation. To this end, it is important to determine which tissue is the most suitable for analysis, and which compounds are the most promising candidates for PMI estimation.
objectivesThis work is aimed at the comparison of human serum, aqueous humor (AH), and vitreous humor (VH) as perspective tissues for metabolomic-based PMI estimation, at the determination of most promising PMI biomarkers, and at the development of method of PMI estimation based on the measurement of concentrations of PMI biomarkers.
methodsQuantitative metabolomic profiling of samples of the human serum, AH, and VH taken at different PMIs has been performed with the use of NMR spectroscopy.
resultsIt is found that the metabolomic changes in anatomically isolated ocular fluids are slower and smoother than that in blood. A good positive time correlation (Pearson coefficient r > 0.5) was observed for several metabolites, including hypoxanthine, choline, creatine, betaine, glutamate, and glycine. A model for PMI estimation based on concentrations of several metabolites in AH and VH is proposed.
conclusionsThe obtained results demonstrate that the metabolomic analysis of AH and VH is more suitable for the PMI estimation than that of serum. The compounds with good positive time correlation can be considered as potential PMI biomarkers.
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