ArticleBiological trace element research2021
Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Melatonin as a protector against endocrine disruption across tissues: A systematic review.Physiological reports · 2026Pooled it
- Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.Archives of women's mental health · 2024Pooled it
- Carvacrol Modulates Cadmium-Induced Behavioral, Biochemical, Histopathological, and Metabolomic Alterations in rats.Biological trace element research · 2026Article
- Differential Sensitivity of Endocrine and Non-Endocrine Tissues to Cadmium-Induced Lipid Peroxidation and the Protective Role of Melatonin.International journal of molecular sciences · 2026Article
- Inhibition of Neuroinflammation by Costunolide Attenuates Hypoxic-Ischemic Brain Damage via the PI3K/AKT Pathway in Neonatal Rats.Molecular neurobiology · 2025Article
- Pineal Gland and Melatonin are Associated with Serum Element Metabolism in Rats.Noro psikiyatri arsivi · 2025Article
- Subchronic Exposure to Mixture of Cadmium, Copper, and Nickel Induces Neurobehavioral Deficits and Hippocampal Oxidative Stress of Wistar Rats.Biological trace element research · 2025Article
- Association of Urinary Cadmium Concentration With Cognitive Impairment in US Adults: A Longitudinal Cohort Study.Neurology · 2024Article
- Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator.Biological trace element research · 2024Article
- Therapeutic potential of rutin in premenstrual depression: evidence fromFrontiers in pharmacology · 2024Article
- Effect of neonatal melatonin administration on behavioral and brain electrophysiological and redox imbalance in rats.Frontiers in neuroscience · 2023Article
- Exogenous melatonin mediates radish (Frontiers in plant science · 2023Article
- Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review.International journal of environmental research and public health · 2022Review
- Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer's disease.Metabolic brain disease · 2022Article
- Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice.Environmental toxicology · 2022Article
- The Oil Formulation Derived fromJournal of experimental pharmacology · 2022Article
- Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats.Frontiers in endocrinology · 2022Article
- Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain.Antioxidants (Basel, Switzerland) · 2021Article
- Effects of Melatonin on Neurobehavior and Cognition in a Cerebral Palsy Model ofFrontiers in endocrinology · 2021Article
- Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats.Environmental analysis, health and toxicology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats received either an intraperitoneal injection of saline solution NaCl (0.9%), Mel (4 mg/kg), Cd (1 mg/kg), or Cd (1 mg/kg) + Mel (4 mg/kg) for 8 weeks. Behavioral disorders were evaluated by different tests mainly the open field and elevated plus maze tests for anxiety-like behavior, forced swimming test (FST) for depression-like behavior, and the Y-maze and Morris water maze (MWM) tests for cognitive disorders. Thereafter, oxidative stress indices and histology of the hippocampus were evaluated. The results confirm that Cd administration has anxiogenic-like effects in both anxiety tests and depressive-like effects in the FST and leads to memory and learning disabilities in the Y-maze and MWM. We also report that Mel counteracts these neurobehavioral disorders. Biochemical assays showed that rats intoxicated with Cd significantly increased levels of nitric oxide (NO) and lipid peroxidation (LPO), while the activities of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased in the hippocampus. In contrast, Mel administration attenuates the Cd-induced changes. The histopathological studies in the hippocampus of rats also supported that Mel markedly reduced the Cd-induced neuronal loss in CA3 sub-region. Overall, our results suggest that Mel could be used to protect against Cd-induced neurobehavioral changes via its antioxidant properties in the hippocampus. The effects of Cd and Mel are sex-dependent, knowing that Cd is more harmful in males, while Mel is more protective in females.
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Registered trials
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