ArticleEuropean journal of applied physiology2020
Muscle pain induced by hypertonic saline in the knee extensors decreases single-limb isometric time to task failure.
Article in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Acute hypoalgesic and neurophysiological responses to lower-limb ischaemic preconditioning.Experimental brain research · 2025Trial
- Activation of skeletal muscle mechanoreceptors and nociceptors reduces the exercise performance of the contralateral homologous muscles.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Trial
- Elevated muscle pain induced by a hypertonic saline injection reduces power output independent of physiological changes during fixed perceived effort cycling.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Trial
- Tramadol is a performance-enhancing drug in highly trained cyclists: a randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Contralateral Thermal Pain and Naturally Occurring Muscle Pain Have Different Effects on Force Production During a Fixed Perceived Effort Handgrip Task.European journal of pain (London, England) · 2026Article
- Experimental acute muscle pain and itch induce similar inhibitory effects on corticospinal excitability.Pain reports · 2025Article
- Investigating the Modulation of Corticomotor and Neuromuscular Function by Contralateral and Ipsilateral Experimental Pain Applied During Cycling.Scandinavian journal of medicine & science in sports · 2025Article
- Sex Is Not an Independent Predictor of Exercise-Induced Pain After Adjustment for Performance and Pain Sensitivity.Pain research & management · 2025Article
- Exercise-induced pain within endurance exercise settings: Definitions, measurement, mechanisms and potential interventions.Experimental physiology · 2024Review
- Intermittent blood flow occlusion modulates neuromuscular, perceptual, and cardiorespiratory determinants of exercise tolerance during cycling.European journal of applied physiology · 2023Article
- Perceived Exertion: Revisiting the History and Updating the Neurophysiology and the Practical Applications.International journal of environmental research and public health · 2022Review
- The effect of hypertonic saline evoked muscle pain on neurophysiological changes and exercise performance in the contralateral limb.Experimental brain research · 2022Article
- The effect of elevated muscle pain on neuromuscular fatigue during exercise.European journal of applied physiology · 2022Article
- Electrically induced quadriceps fatigue in the contralateral leg impairs ipsilateral knee extensors performance.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Gait Adaptation to a Phase-Specific Nociceptive Electrical Stimulation Applied at the Ankle: A Model to Study Musculoskeletal-Like Pain.Frontiers in human neuroscience · 2021Article
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Authors and funding
4 authors.
Funding
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Abstract
purposeIncreased nociceptive activity and the experience of exercise-induced pain (EIP) may contribute to fatigue during endurance exercise. To investigate this, a pain model that produces pain similar to EIP and decouples its relationship to exercise intensity is required. This study (1) compared the quality of pain caused by a hypertonic saline injection into the vastus lateralis in resting and exercise conditions, and (2) investigated whether this pain contributes to changes in time to task failure.
methodsOn separate days, 18 participants completed a time to task failure at 20% maximal voluntary torque (MVT), a resting hypertonic saline intramuscular injection, and in a further three visits a time to task failure at 10% MVT following injection of isotonic saline, hypertonic saline or a control (no injection).
resultsIn a subset of eligible participants (n = 12), the hypertonic saline combined with 10% MVT produced a qualitative experience of pain (assessed by the McGill Pain Questionnaire) that felt similar to EIP. 10% MVT with hypertonic saline significantly elevated pain intensity in the first 20% of the time to task failure and caused a significantly (P < 0.05) shorter time to task failure (448 ± 240 s) compared with the isotonic saline (605 ± 285 s) and control (514 ± 197 s) conditions.
conclusionThese findings demonstrate that hypertonic saline increases the intensity of pain during exercise, which results in a faster occurrence of exercise-induced fatigue. These results provide important evidence supporting pain as a limiting factor in endurance performance.
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