Evidence map›Paper›PMID 32613424›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2020

Post-mortem histopathology of a pediatric brain after bilateral DBS of GPI for status dystonicus: case report and review of the literature.

Flavio Giordano, Chiara Caporalini, Simone Peraio, Lorenzo Mongardi, Anna Maria Buccoliero, Michele Alessandro Cavallo, Lorenzo Genitori, Matteo Lenge, Regina Mura, Federico Melani and 3 more

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Flavio GiordanoDepartment of Neurosurgery, Children's Hospital A. Meyer-University of Florence, Florence, Italy. flavio.giordano@meyer.it.ORCID 0000-0002-9006-9225
Chiara CaporaliniDivision of Pathology, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Simone PeraioDepartment of Neurosurgery, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Lorenzo MongardiDepartment of Neurosurgery, Sant'Anna Hospital University of Ferrara, Ferrara, Italy.
Anna Maria BuccolieroDivision of Pathology, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Michele Alessandro CavalloDepartment of Neurosurgery, Sant'Anna Hospital University of Ferrara, Ferrara, Italy.
Lorenzo GenitoriDepartment of Neurosurgery, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Matteo LengeDepartment of Neurosurgery, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Regina MuraDepartment of Neurosurgery, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Federico MelaniChild Neurology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Manuela L'ErarioPediatric Anesthesiology and Intensive Care Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Leonardo LelliDiagnostic Imaging Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Michele PennicaPediatric Anesthesiology and Intensive Care Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Meyer Children's Hospital · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effects of deep brain stimulation (DBS) electrodes on the brain of a dystonic pediatric patient submitted to bilateral DBS of the globus pallidus internus (GPI).

methodsAn 8-year-old male patient underwent bilateral DBS of GPI for status dystonicus. He died 2 months later due to multiorgan failure triggered by bacterial pneumonia. A post-mortem pathological study of the brain was done.

resultsAt visual inspection, no grossly apparent softening, hemorrhage, or necrosis of the brain adjacent to the DBS lead tracts was detected. High-power microscopic examination of the tissue surrounding the electrode trajectories showed lymphocyte infiltration, astrocytic gliosis, microglia, macrophages, and clusters of multinucleate giant cells. Significant astrocytosis was confirmed by GFAP staining in the electrode site. The T cell lymphocyte activity was overexpressed with activated macrophages detected with CD3, CD20, CD45, and CD68 stains respectively. There was no gliosis or leukocyte infiltration away from the surgical tracks of the electrodes.

conclusionThis is the first post-mortem examination of a child's brain after bilateral DBS of GPI. The comparison with adult post-mortem reports showed no significant differences and confirms the safety of DBS implantation in the pediatric population too.

Indexed as

Deep Brain StimulationGlobus PallidusAutopsyChildHumansMaleTreatment OutcomeAutopsyDeep brain stimulationFunctional neurosurgeryGlobus pallidus internusHistopathology

Identifiers

PMID32613424
OpenAlexW3039047012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.