ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020
Risk of fragility fractures in obesity and diabetes: a retrospective analysis on a nation-wide cohort.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Artificial intelligence in osteoporosis screening and fracture risk prediction among aging populations: a bibliometric evidence map.Frontiers in endocrinology · 2026Pooled it
- Diagnosing Osteoporosis in Diabetes-A Systematic Review on BMD and Fractures.Current osteoporosis reports · 2024Pooled it
- Reduced postprandial bone resorption and greater rise in GLP-1 in overweight and obese individuals after an α-glucosidase inhibitor: a double-blinded randomized crossover trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Trial
- Type 1 and 2 diabetes mellitus: comprehensive fracture risk relationships in UK Biobank.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- The Effects of Obesity and Weight Loss Interventions on Bone Health: A Narrative Review.Current diabetes reports · 2025Review
- Are low-trauma fractures all fragility fractures? Insights into musculoskeletal and body composition characteristics of community-dwelling post-menopausal women with a recent fracture.Aging clinical and experimental research · 2025Article
- Bone Fragility in High Fat Diet-induced Obesity is Partially Independent of Type 2 Diabetes in Mice.Calcified tissue international · 2024Article
- Vitamin D level as a predictor of dysmobility syndrome with type 2 diabetes.Scientific reports · 2024Article
- Article
- Obesity and Skeletal Fragility.The Journal of clinical endocrinology and metabolism · 2024Review
- Obesity and periodontitis: a comprehensive review of their interconnected pathophysiology and clinical implications.Frontiers in nutrition · 2024Review
- Associations of dietary oxidative balance score with femur osteoporosis in postmenopausal women: data from the National Health and Nutrition Examination Survey.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Assessment of osteoporosis in patients with type 2 diabetes mellitus: A study from the central region of Saudi Arabia.Saudi medical journal · 2023Article
- The Effect of Obesity on Distal Radius Fractures: An Analysis from the NSQIP Database.Plastic and reconstructive surgery. Global open · 2023Article
- Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications.Healthcare (Basel, Switzerland) · 2023Article
- The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis.Frontiers in endocrinology · 2023Review
- Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus.Acta diabetologica · 2022Article
- Obesity, Bone Loss, and Periodontitis: The Interlink.Biomolecules · 2022Review
- Association between long-term exposure to air pollution and immune-mediated diseases: a population-based cohort study.RMD open · 2022Observational
- Association between exposure to fine particulate matter and osteoporosis: a population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the role of obesity and diabetes on bone health in a nation-wide cohort of women with high risk of fracture.
introductionThe role of obesity and diabetes on fracture risk is yet poorly understood. Body mass index (BMI) and bone mineral density (BMD) are strongly correlated; however, patients with elevated BMI are not protected against fractures, configuring the obesity paradox. A similar controversial association has been also found in diabetic patients. Herein, we present a retrospective analysis on 59,950 women.
methodsUsing a new web-based fracture risk-assessment tool, we have collected demographic (including BMI), densitometric, and clinical data (including history of vertebral or hip and non-vertebral, non-hip fractures, presence of comorbidities). We performed a propensity score generation with 1:1 matching for patients in the obese (BMI ≥ 30) and non-obese (BMI < 30) groups, in the diabetics and non-diabetics. Propensity score estimates were estimated using a logistic regression model derived from the clinical variables: age, lumbar spine T-score, and femoral neck T-score.
resultsWe found an association between diabetes and fractures of any kind (OR 1.3, 95% CI 1.1-1.4 and 1.3, 95% CI 1.2-1.5 for vertebral or hip fractures and non-vertebral, non-hip fractures, respectively). Obesity, on the other hand, was significantly associated only with non-vertebral, non-hip fractures (OR 1.3, 95% CI 1.1-1.6). To estimate the individual effect of obesity and diabetes on bone health, we ran sensitivity analyses which included obese non-diabetic patients and non-obese diabetic patients, respectively.
conclusionsNon-obese diabetics had the highest risk of vertebral or hip fracture, whereas obese non-diabetics predominantly had non-vertebral, non-hip fracture's risk. These results should raise awareness in clinical practice when evaluating diabetic and/or obese patients.
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