Evidence map›Paper›PMID 32613246›Full record

ArticleSocial cognitive and affective neuroscience2020

Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer's disease.

Aurélie L Manuel, Daniel Roquet, Ramon Landin-Romero, Fiona Kumfor, Rebekah M Ahmed, John R Hodges, Olivier Piguet

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In one paragraph

Article in Social cognitive and affective neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aurélie L ManuelSchool of Psychology, The University of Sydney, Sydney, Australia.
Daniel RoquetSchool of Psychology, The University of Sydney, Sydney, Australia.
Ramon Landin-RomeroSchool of Psychology, The University of Sydney, Sydney, Australia.
Fiona KumforSchool of Psychology, The University of Sydney, Sydney, Australia.
Rebekah M AhmedBrain & Mind Centre, The University of Sydney, Sydney, Australia.
John R HodgesBrain & Mind Centre, The University of Sydney, Sydney, Australia.
Olivier PiguetSchool of Psychology, The University of Sydney, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Negative and positive emotions are known to shape decision-making toward more or less impulsive responses, respectively. Decision-making and emotion processing are underpinned by shared brain regions including the ventromedial prefrontal cortex (vmPFC) and the amygdala. How these processes interact at the behavioral and brain levels is still unclear. We used a lesion model to address this question. Study participants included individuals diagnosed with behavioral-variant frontotemporal dementia (bvFTD, n = 18), who typically present deficits in decision-making/emotion processing and atrophy of the vmPFC, individuals with Alzheimer's disease (AD, n = 12) who present with atrophy in limbic structures and age-matched healthy controls (CTRL, n = 15). Prior to each choice on the delay discounting task participants were cued with a positive, negative or neutral picture and asked to vividly imagine witnessing the event. As hypothesized, our findings showed that bvFTD patients were more impulsive than AD patients and CTRL and did not show any emotion-related modulation of delay discounting rate. In contrast, AD patients showed increased impulsivity when primed by negative emotion. This increased impulsivity was associated with reduced integrity of bilateral amygdala in AD but not in bvFTD. Altogether, our results indicate that decision-making and emotion interact at the level of the amygdala supporting findings from animal studies.

Indexed as

AgedAlzheimer DiseaseAtrophyDecision MakingEmotionsFemaleFrontotemporal DementiaHumansImpulsive BehaviorMaleMiddle AgedNeuropsychological TestsPrefrontal Cortexamygdaladelay discountingemotionventromedial prefrontal cortexvoxel-based morphometry

Identifiers

PMID32613246
PMCPMC7393308

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.