Evidence map›Paper›PMID 32613226›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2021

The relationship of cognitive change over time to the self-reported Ascertain Dementia 8-item Questionnaire in a general population.

Jesse S Passler, Richard E Kennedy, Michael Crowe, Olivio J Clay, Virginia J Howard, Mary Cushman, Frederick W Unverzagt, Virginia G Wadley

Abstract read
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In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Factors associated with subjective cognitive complaints in former American football players.Journal of the International Neuropsychological Society : JINS · 2026
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jesse S PasslerDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Richard E KennedyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Michael CroweDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Olivio J ClayDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Virginia J HowardDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mary CushmanDepartment of Medicine, University of Vermont, Burlington, VT, USA.
Frederick W UnverzagtDepartment of Psychiatry, Indiana University, Bloomington, IN, USA.
Virginia G WadleyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

objectiveThe aim of the study was to examine the relationship between longitudinally assessed cognitive functioning and self-reported dementia status using the Ascertain Dementia 8-item questionnaire (AD8) in a national population-based sample.

methodsThe analysis included 14,453 participants from the REasons for Geographic and Racial Differences in Stroke study. A validated cutoff of ≥2 symptoms endorsed on the AD8 (administered 10 years after enrollment) represented positive AD8 status. Incident cognitive impairment was defined as change from intact to impaired status in the Six-Item Screener score, and cognitive decline was defined by trajectories of Letter "F" Fluency from the Montreal Cognitive Assessment, and Animal Fluency, Word List Learning, and Word List Delayed recall, all from the Consortium to Establish a Registry for Alzheimer's Disease battery. Logistic regression models controlled for demographics, health variables, and depressive symptoms.

resultsSensitivity and specificity of the AD8 to detect incident cognitive impairment were 45.2% and 78.4%, respectively. Incident cognitive impairment and a one-word decline in WLL increased the odds of self-reported positive AD8 by 96% (95% CI: 1.68-2.28) and 27% (95% CI: 1.17-1.37), respectively. There was a strong association between high depression risk and self-reported positive AD8 in sensitivity analyses.

conclusionsIncident cognitive impairment and high depression risk were the strongest predictors of self-reported positive AD8 in this population-based sample. Our results inform the utility of the AD8 as a self-report measure in a large, national sample that avoids selection biases inherent in clinic-based studies. The AD8 is screening measure and should not be used to diagnose dementia clinically.

Indexed as

Cognitive DysfunctionCognitionHumansNeuropsychological TestsSelf ReportSurveys and QuestionnairesCardiovascular diseaseCerebrovascular disease/accident and strokeDementiaDepressionElderly/geriatrics/agingMild cognitive impairment

Identifiers

PMID32613226
PMCPMC7881974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.