ArticleAnimal models and experimental medicine2020
Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease.
Article in Animal models and experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Enhanced atherosclerosis in apolipoprotein E knockout rabbits: role of apoB48-rich remnant lipoproteins.Frontiers in cardiovascular medicine · 2024Article
- Spatially resolved transcriptomics for evaluation of intracranial vessels in a rabbit model: Proof of concept.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke.Journal of visualized experiments : JoVE · 2023Article
- Pathological Investigations of Intracranial Atherosclerosis Using Multiple Hypercholesterolemic Rabbit Models.Frontiers in endocrinology · 2022Article
- Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI.The neuroradiology journal · 2021Article
- Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease.Animal models and experimental medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemic stroke. Poor understanding of the disease due to limited human data leads to imprecise treatment. Apolipoprotein E knockout (ApoE-KO) rabbits were compared to an existing model, the Watanabe heritable hyperlipidemic (WHHL) rabbit, and wild-type New Zealand white (NZW) rabbit controls. Intracranial artery samples were assessed on histopathology for the presence of ICAD. Logistic and ordinal regression analyses were performed to assess for disease presence and severity, respectively. Eighteen rabbits and 54 artery segments were analyzed. Univariate logistic analysis confirmed the presence of ICAD in model rabbits (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.