ArticleAnimal models and experimental medicine2020
Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary artery constriction model.
Article in Animal models and experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model.Journal of clinical medicine · 2026Article
- Cardiac fibrosis: from mechanisms and models to medicines.Trends in pharmacological sciences · 2025Review
- Distinct Right Ventricular Performance in Response to Acute Colchicine Treatment in Healthy and Diseased States.Function (Oxford, England) · 2025Article
- Septal annular dilation in chronic ovine functional tricuspid regurgitation.The Journal of thoracic and cardiovascular surgery · 2023Article
- Valvular complex and tissue remodelling in ovine functional tricuspid regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
- Alterations of biaxial viscoelastic properties of the right ventricle in pulmonary hypertension development in rest and acute stress conditions.Frontiers in bioengineering and biotechnology · 2023Article
- Strain-dependent stress relaxation behavior of healthy right ventricular free wall.Acta biomaterialia · 2022Article
- Progression Toward Decompensated Right Ventricular Failure in the Ovine Pulmonary Hypertension Model.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2022Article
- Preclinical models of congestive heart failure, advantages, and limitations for application in clinical practice.Frontiers in physiology · 2022Review
- The Interventricular Septum Is Biomechanically Distinct from the Ventricular Free Walls.Bioengineering (Basel, Switzerland) · 2021Article
- Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary artery constriction model.Animal models and experimental medicine · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRight ventricle failure (RVF) is associated with serious cardiac and pulmonary diseases that contribute significantly to the morbidity and mortality of patients. Currently, the mechanisms of RVF are not fully understood and it is partly due to the lack of large animal models in adult RVF. In this study, we aim to establish a model of RVF in adult ovine and examine the structure and function relations in the RV.
methodsRV pressure overload was induced in adult male sheep by revised pulmonary artery constriction (PAC). Briefly, an adjustable hydraulic occluder was placed around the main pulmonary artery trunk. Then, repeated saline injection was performed at weeks 0, 1, and 4, where the amount of saline was determined in an animal-specific manner. Healthy, age-matched male sheep were used as additional controls. Echocardiography was performed bi-weekly and on week 11 post-PAC, hemodynamic and biological measurements were obtained.
resultsThis PAC methodology resulted in a marked increase in RV systolic pressure and decreases in stroke volume and tricuspid annular plane systolic excursion, indicating signs of RVF. Significant increases in RV chamber size, wall thickness, and Fulton's index were observed. Cardiomyocyte hypertrophy and collagen accumulation (particularly type III collagen) were evident, and these structural changes were correlated with RV dysfunction.
conclusionIn summary, the animal-specific, repeated PAC provided a robust approach to induce adult RVF, and this ovine model will offer a useful tool to study the progression and treatment of adult RVF that is translatable to human diseases.
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