ReviewFrontiers in chemistry2020
Recent Progress in Chemo-Enzymatic Methods for the Synthesis of N-Glycans.
Review in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Genetic evolution analysis and clinical antibody tracking analysis of two PEDV strains in China.Veterinary research communications · 2026Article
- Site-directed mutagenesis leads to the optimized transglycosylation activity of endo-beta-N-acetylglucosaminidase from Trypanosoma brucei.Glycoconjugate journal · 2024Article
- Review
- A First Expression, Purification and Characterization of Endo-β-1,3-Glucanase fromJournal of fungi (Basel, Switzerland) · 2023Article
- Recent Progress in 1,2-Molecules (Basel, Switzerland) · 2023Review
- Cell-freeFrontiers in molecular biosciences · 2023Article
- Site Specific Preparation of N-Glycosylated Peptides: Thioamide-Directed Activation of Aspartate.Angewandte Chemie (International ed. in English) · 2022Article
- New insight into strategies used to develop long-acting G-CSF biologics for neutropenia therapy.Frontiers in oncology · 2022Review
- Recent Chemical and Chemoenzymatic Strategies to Complex-TypeFrontiers in chemistry · 2022Review
- General Tolerance of Galactosyltransferases toward UDP-galactosamine Expands Their Synthetic Capability.Angewandte Chemie (International ed. in English) · 2021Article
- Cellular and Molecular Engineering of Glycan Sialylation in Heterologous Systems.Molecules (Basel, Switzerland) · 2021Review
- Capillary Nanogel Electrophoresis for the Determination of the β1-4 Galactosyltransferase Michaelis-Menten Constant and Real-Time Addition of Galactose Residues toAnalytical chemistry · 2021Article
- Recent Advances in the Chemical Biology ofMolecules (Basel, Switzerland) · 2021Review
- The Abnormal Glycopatterns of Salivary Glycoproteins in Esophageal Squamous Cell Carcinoma Patients.Frontiers in chemistry · 2021Article
- Nucleotide Sugars in Chemistry and Biology.Molecules (Basel, Switzerland) · 2020Review
- From glycosylation to deglycosylation: Unraveling the complete deglycosylation processing pathway ofScience progressReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asparagine (N)-linked glycosylation is one of the most common co- and post-translational modifications of both intra- and extracellularly distributing proteins, which directly affects their biological functions, such as protein folding, stability and intercellular traffic. Production of the structural well-defined homogeneous N-glycans contributes to comprehensive investigation of their biological roles and molecular basis. Among the various methods, chemo-enzymatic approach serves as an alternative to chemical synthesis, providing high stereoselectivity and economic efficiency. This review summarizes some recent advances in the chemo-enzymatic methods for the production of N-glycans, including the preparation of substrates and sugar donors, and the progress in the glycosyltransferases characterization which leads to the diversity of N-glycan synthesis. We discuss the bottle-neck and new opportunities in exploiting the chemo-enzymatic synthesis of N-glycans based on our research experiences. In addition, downstream applications of the constructed N-glycans, such as automation devices and homogeneous glycoproteins synthesis are also described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.