Evidence map›Paper›PMID 32612959›Full record

ArticleFrontiers in cellular and infection microbiology2020

Whole-Genome Approach to Assessing Human Cytomegalovirus Dynamics in Transplant Patients Undergoing Antiviral Therapy.

Nicolás M Suárez, Emily Blyth, Kathy Li, Tina Ganzenmueller, Salvatore Camiolo, Selmir Avdic, Barbara Withers, Silvia Linnenweber-Held, Wilfried Gwinner, Akshay Dhingra and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  4. Genomic and geographical structure of human cytomegalovirus.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Nicolás M SuárezMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Emily BlythWestmead Institute for Medical Research, Sydney, NSW, Australia.
Kathy LiMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Tina GanzenmuellerInstitute for Medical Virology, University Hospital Tübingen, Tübingen, Germany.
Salvatore CamioloMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Selmir AvdicWestmead Institute for Medical Research, Sydney, NSW, Australia.
Barbara WithersWestmead Institute for Medical Research, Sydney, NSW, Australia.
Silvia Linnenweber-HeldDepartment of Nephrology, Hannover Medical School, Hanover, Germany.
Wilfried GwinnerDepartment of Nephrology, Hannover Medical School, Hanover, Germany.
Akshay DhingraInstitute of Virology, Hannover Medical School, Hanover, Germany.
Albert HeimInstitute of Virology, Hannover Medical School, Hanover, Germany.
Thomas F SchulzInstitute of Virology, Hannover Medical School, Hanover, Germany.
Rory GunsonWest of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, Glasgow, United Kingdom.
David GottliebWestmead Institute for Medical Research, Sydney, NSW, Australia.
Barry SlobedmanDiscipline of Infectious Diseases and Immunology, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Andrew J DavisonMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Medizinische Hochschule Hannover · DEMRC University of Glasgow Centre for Virus Research · GBWestmead Institute for Medical Research · AUGlasgow Royal Infirmary · GBThe University of Sydney · AUWestmead Hospital · AU

Funding

Medical Research Council MC_UU_12014/3Wellcome TrustWellcome Trust 204870/Z/16/Z
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is the most frequent cause of opportunistic viral infection following transplantation. Viral factors of potential clinical importance include the selection of mutants resistant to antiviral drugs and the occurrence of infections involving multiple HCMV strains. These factors are typically addressed by analyzing relevant HCMV genes by PCR and Sanger sequencing, which involves independent assays of limited sensitivity. To assess the dynamics of viral populations with high sensitivity, we applied high-throughput sequencing coupled with HCMV-adapted target enrichment to samples collected longitudinally from 11 transplant recipients (solid organ,

Indexed as

CytomegalovirusCytomegalovirus InfectionsAntiviral AgentsDNA, ViralDrug Resistance, ViralGanciclovirHumansAntiviral AgentsDNA, ViralGanciclovirantiviral therapygenome sequencehuman cytomegalovirusmultiple-strain infectionresistance mutationtarget enrichmenttransplantation

Identifiers

PMID32612959
PMCPMC7308726
OpenAlexW3024630394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.