Evidence map›Paper›PMID 32612816›Full record

Trial reportJournal of global health2020

Effects of therapeutic zinc supplementation for diarrhea and two preventive zinc supplementation regimens on the incidence and duration of diarrhea and acute respiratory tract infections in rural Laotian children: A randomized controlled trial.

Maxwell A Barffour, Guy-Marino Hinnouho, K Ryan Wessells, Sengchanh Kounnavong, Kethmany Ratsavong, Dalaphone Sitthideth, Bangone Bounheuang, Khanpaseuth Sengnam, Bigphone Chanhthavong, Charles D Arnold and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of global health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02428647 (Lao Zinc Study), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428647 nacompletednot on this map

Lao Zinc Study: The Effects of Two Forms of Daily Preventive Zinc Supplementation Versus Therapeutic Zinc Supplementation for Diarrhea on Young Children's Physical Growth and Risk of New Episodes of Diarrhea

TypeinterventionalSponsorUniversity of California, DavisRan2015 to 2017Enrolled3,433ConditionsDiarrheaArmsMNP, preventive zinc supplement, therapeutic zinc supplement, preventive placebo supplement, therapeutic placebo supplement
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  3. Zinc for prevention and treatment of the common cold.The Cochrane database of systematic reviews · 2024
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  16. The Role of Micronutrients and Toxic Metals in the Management of Epidemics in Cambodia.International journal of environmental research and public health · 2021
    Review
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Maxwell A BarffourInstitute for Global Nutrition, University of California, Davis, California, USA.
Guy-Marino HinnouhoInstitute for Global Nutrition, University of California, Davis, California, USA.
K Ryan WessellsInstitute for Global Nutrition, University of California, Davis, California, USA.
Sengchanh KounnavongLao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
Kethmany RatsavongLao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
Dalaphone SitthidethLao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
Bangone BounheuangLao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
Khanpaseuth SengnamLao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
Bigphone ChanhthavongLao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
Charles D ArnoldInstitute for Global Nutrition, University of California, Davis, California, USA.
Kenneth H BrownInstitute for Global Nutrition, University of California, Davis, California, USA.
Charles P LarsonSchool of Population and Global Health, McGill University, Montreal, Canada.
Sonja Y HessInstitute for Global Nutrition, University of California, Davis, California, USA.
Public Health Institute · USUniversity of California, Davis · USMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiarrhea and respiratory tract infections are leading causes of childhood morbidity and mortality. This individually randomized, double-blind placebo-controlled trial was designed to evaluate the effects of different zinc supplementation regimens on the incidence and duration of diarrhea and acute lower (ALRI) and upper (AURI) respiratory tract infections among rural Laotian children. The study included 3407 children, 6-23 months at enrollment.

methodsChildren were randomized to one of four study groups: therapeutic zinc supplements for diarrhea treatment (20 mg/d for 10 days with each episode; TZ), daily preventive zinc tablets (7 mg/d; PZ), daily multiple micronutrient powder (10 mg/d zinc, 6 mg/d iron and 13 other micronutrients; MNP), or daily placebo powder for 9 months. Incidence and duration of diarrhea (≥3 liquid stools/24 hours), ALRI (persistent cough with wheezing, stridor or chest in-drawing) and AURI (purulent nasal discharge with cough) were assessed by parental report during weekly home visits and analyzed using negative binomial models.

resultsBaseline mean age was 14.2 ± 5.1 months, and 71% had low plasma zinc (<65 μg/dL). Overall diarrhea incidence (0.61 ± 0.01 episodes/100 days at risk) and duration (2.12 ± 0.03 days/episode) did not differ by study group. Age modified the impact of the interventions on diarrhea incidence (

conclusionsThere was no overall impact of TZ, PZ or MNP on diarrhea, ALRI and AURI. However, in children >18 months, TZ significantly reduced both the duration of diarrhea episodes and the incidence of future diarrhea episodes compared with placebo.

trial registrationClinicalTrials.gov: NCT02428647.

Indexed as

Dietary SupplementsDiarrheaDouble-Blind MethodFemaleHumansIncidenceInfantLaosMaleRespiratory Tract InfectionsRural PopulationTreatment OutcomeZincZinc

Identifiers

PMID32612816
PMCPMC7321011
OpenAlexW3037389148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.