Evidence map›Paper›PMID 32612741›Full record

ArticleProceedings of meetings on acoustics. Acoustical Society of America2018

Update on clinical trials of kidney stone repositioning and preclinical results of stone breaking with one system.

M R Bailey, Y N Wang, W Kreider, J C Dai, B W Cunitz, J D Harper, H Chang, M D Sorensen, Z Liu, O Levy and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of meetings on acoustics. Acoustical Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Journal of endourology · 2020
    Article
  6. Noninvasive acoustic manipulation of objects in a living body.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Review
  8. Article
  9. DESIGN OF A TRANSDUCER FOR FRAGMENTING LARGE KIDNEY STONES USING BURST WAVE LITHOTRIPSY.Proceedings of meetings on acoustics. Acoustical Society of America · 2018
    Article
  10. Summary of "Biomedical Acoustics and Physical Acoustics: Shock Waves and Ultrasound for Calculus Fragmentation".Proceedings of meetings on acoustics. Acoustical Society of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

M R BaileyCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St., Seattle, WA 98105, USA.
Y N WangCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St., Seattle, WA 98105, USA.
W KreiderCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St., Seattle, WA 98105, USA.
J C DaiDepartment of Urology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356510, Seattle, WA 98195.
B W CunitzCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St., Seattle, WA 98105, USA.
J D HarperDepartment of Urology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356510, Seattle, WA 98195.
H ChangDepartment of Urology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356510, Seattle, WA 98195.
M D SorensenDepartment of Urology, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356510, Seattle, WA 98195.
Z LiuDepartment of Biostatistics, Indiana University-Purdue University Indianapolis, 410 W. Tenth St., Suite 3000., Indianapolis, IN 46202, USA.
O LevySonoMotion, Inc., 415 Grand Ave, Suite 302, South San Francisco, CA 94080.
B DunmireCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St., Seattle, WA 98105, USA.
A D MaxwellCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St., Seattle, WA 98105, USA.
University of Washington · USJohns Hopkins University Applied Physics Laboratory · USUniversity of Washington Applied Physics Laboratory · USIndiana University – Purdue University Indianapolis · USSonomotion (United States) · US

Funding

SWL AND RENAL INJURY AND STONE COMMINUTIONP01DK043881 · NIDDK · UNIVERSITY OF WASHINGTON · PI BAILEY, MICHAEL R · 1994 to 2023
$33.5M
First-In-Human Feasibility Trial of Break Wave - The Office-Based Lithotripsy SolutionR44DK109779 · NIDDK · SONOMOTION, INC. · PI LEVY, OREN · 2016 to 2021
$4.6M
Noninvasive fragmentation of urinary calculi with focused ultrasound burstsK01DK104854 · NIDDK · UNIVERSITY OF WASHINGTON · PI MAXWELL, ADAM DOUGLAS · 2015 to 2019
$686k
NIDDK NIH HHS K01 DK104854NIDDK NIH HHS P01 DK043881NIDDK NIH HHS R44 DK109779
6 · The paper itself

Abstract

Our goal is an office-based, handheld ultrasound system to target, detach, break, and/or expel stones and stone fragments from the urinary collecting system to facilitate natural clearance. Repositioning of stones in humans (maximum 2.5 MPa, and 3-second bursts) and breaking of stones in a porcine model (maximum 50 cycles, 20 Hz repetition, 30 minutes, and 7 MPa peak negative pressure) have been demonstrated using the same 350-kHz probe. Repositioning in humans was conducted during surgery with a ureteroscope in the kidney to film stone movement. Independent video review confirmed stone movements (≥ 3 mm) in 15 of 16 kidneys (94%). No serious or unanticipated adverse events were reported. Experiments of burst wave lithotripsy (BWL) effectiveness on breaking human stones implanted in the porcine bladder and kidney demonstrated fragmentation of 8 of 8 stones on post mortem dissection. A 1-week survival study with the BWL exposures and 10 specific-pathogen-free pigs, showed all findings were within normal limits on clinical pathology, hematology, and urinalysis. These results demonstrate that repositioning of stones with ultrasonic propulsion and breaking of stones with BWL are safe and effective.

Identifiers

PMID32612741
PMCPMC7328990
OpenAlexW2906160892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.