Evidence map›Paper›PMID 32612738›Full record

ArticleThe World Allergy Organization journal2020

Skin prick reactivity among asthmatics in East Africa.

Richard Kwizera, Vincent Wadda, Levicatus Mugenyi, Hellen Aanyu-Tukamuhebwa, George Nyale, Getnet Yimer, Jeremiah Chakaya, Corina De Jong, Thys Van der Molen, David W Denning and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03065920 (African Severe Asthma Program), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03065920 completednot on this map

African Severe Asthma Program

Typeobservational_patient_registrySponsorMakerere UniversityRan2016 to 2019Enrolled1,676ConditionsSevere Asthma
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. [Sensitization characteristics of cockroach in Beijing area].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Article
  7. Review
  8. Article
  9. Prevalence ofTherapeutic advances in infectious disease
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 5 countries.

Richard KwizeraTranslational Research Laboratry, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Vincent WaddaDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Levicatus MugenyiMakerere University Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Hellen Aanyu-TukamuhebwaMakerere University Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
George NyaleRespiratory and Infectious Diseases Unit, Kenyatta National Hospital, Nairobi, Kenya.
Getnet YimerCollege of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Jeremiah ChakayaKenya Medical Research Institute, Nairobi, Kenya.
Corina De JongDepartment of Primary Care Respiratory Medicine, University of Groningen, Netherlands.
Thys Van der MolenDepartment of Primary Care Respiratory Medicine, University of Groningen, Netherlands.
David W DenningThe National Aspergillosis Centre, Wythenshawe Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Robin GoreCambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Bruce J KirengaMakerere University Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Makerere University · UGMulago Hospital · UGUniversity of Groningen · NLAddis Ababa University · ETCambridge University Hospitals NHS Foundation Trust · GBInfectious Diseases Institute · UGKenya Medical Research Institute · KEKenyatta National Hospital · KEManchester Academic Health Science Centre · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundThe burden of asthma in Africa is high, and yet the disease is not universally prioritised. Data on allergic asthma and its impact on asthma morbidity are limited in Africa. Our aim was to describe the distribution of skin prick positivity among asthmatics in Eastern Africa.

methodsFrom August 2016 to May 2018, 1671 asthmatic patients were enrolled from Uganda, Kenya, and Ethiopia as part of the African Severe Asthma Program clinical study. Skin prick testing was performed at baseline using a panel of 12 allergens, and factors associated with skin prick reactivity determined.

resultsOf the 1, 671 patients recruited, 71% were female with a median age of 40 years, 93.6% were aged >15 years and the patterns of asthma symptom frequency was intermittent in 2.9%, mild persistent in 19.9%, moderate persistent in 42.6% and severe persistent in 34.6% at baseline. Self-reported triggers, were dust (92%), cold weather (89%), upper respiratory infections (84%), strong smells (79%) and exposure to tobacco (78%). The majority (90%) of the participants had at least 1 positive allergen reaction, with 0.9% participants reacting to all the 12 allergens. Participants commonly reacted to house dust mites (66%),

conclusionThere is a high prevalence of skin prick positivity among East African patients with asthma, with the commonest allergen being house dust mite. Skin reactivity did not correlate well with asthma severity and poor asthma control. The relation between atopy, measured through skin prick testing, and measures of asthma control among asthma patients in Eastern Africa is unclear and needs further study.

trial registrationThe ASAP study was registered prospectively. ClinicalTrials.gov Identifier: NCT03065920; Registration date: February 28, 2017; Last verified: February 28, 2017.

Indexed as

ACT, Asthma control testAfricaA. fumigatus, Aspergillus fumigatusAllergyAQLQ, Asthma Quality of Life QuestionnaireASAP, African Severe Asthma ProjectAsthmaAtopyCOPD, Chronic obstructive pulmonary diseaseEast AfricaFEV, Forced Expiratory VolumeHIV, Human immunodeficiency virusIg, ImmunoglobulinIQR, Interquartile rangeSPTSPT, Skin prick testingTB, Tuberculosis

Identifiers

PMID32612738
PMCPMC7322185
OpenAlexW3026106135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.