Evidence map›Paper›PMID 32612737›Full record

ArticleThe World Allergy Organization journal2020

Nasal IgE in subjects with allergic and non-allergic rhinitis.

Jonas Eckrich, Julia Hinkel, Anna Fischl, Eva Herrmann, Gabriele Holtappels, Claus Bachert, Stefan Zielen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02810535 (Local IgE in Subjects With Allergic or Non-allergic Rhinitis), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02810535 nacompletednot on this map

Local IgE in Subjects With Allergic or Non-allergic Rhinitis

TypeinterventionalSponsorJohann Wolfgang Goethe University HospitalRan2016 to 2017Enrolled150ConditionsPerennial RhinitisArmsObservation
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Nasal and Serum Immunoglobulin E Levels in Symptomatic Allergic Rhinitis Patients: A Case-Control Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  5. Local allergic rhinitis: considerations.Multidisciplinary respiratory medicine · 2023
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jonas EckrichDepartment of Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Julia HinkelDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.
Anna FischlDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.
Eva HerrmannInstitute of Biostatistics and Mathematical Modeling, Goethe University, Frankfurt, Germany.
Gabriele HoltappelsUpper Airways Research Laboratory, Ghent University, B-9000 Ghent, Belgium.
Claus BachertUpper Airways Research Laboratory, Ghent University, B-9000 Ghent, Belgium.
Stefan ZielenDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.
Goethe University Frankfurt · DEGhent University · BEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students.

methods131 students (age 25.0 ± 5.1 years) with a possible allergic rhinitis and 25 non-allergic controls without rhinitis symptoms (age 22.0 ± 2.0 years) were recruited by public postings. 97 of 131 students with rhinitis were tested positive (≥3 mm) to prick testing with 17 frequent allergens at visit 1. Twenty-four 24 subjects with a house dust mite allergy, 21 subjects with a non-allergic rhinitis, and 18 non-allergic controls were further investigated at visit 2. Blood samples were taken, and nasal secretion was examined. In addition, all groups performed a nasal provocation test with house dust mite (HDM).

resultsIn serum and nasal secretion, total IgE and house dust mite specific IgE significantly differed between HDM positive subjects and controls. However, no differences between non-allergic subjects and control subjects were quantifiable. Neither a nasal provocation test nor a nasal IgE to HDM allergens showed a measurable positive response in any of the non-allergic rhinitis subjects as well as the healthy controls, whilst being positive in 13 subjects with HDM allergy.

conclusionsNasal IgE is present in subjects with HDM allergy, but not in non-allergic rhinitis. In the investigated non-selected population, exclusive local production of IgE is absent. By implication, therefore, our findings challenge the emerging concept of local allergic rhinitis.Study identifier at ClinicalTrials.gov: NCT02810535.

Indexed as

Allergic rhinitisAR, allergic rhinitisAR + HDM, allergic rhinitis with house dust mite allergyD1, Dermatophagoides pteronyssinusD2, Dermatophagoides farinaeFEV1, forced expiratory volume in one secondFVC, forced vital capacityGCP, Good Clinical PracticeHDM, house dust miteHouse dust mite allergyISAAC, International Study of Asthma and Allergies in Childhood questionnaireLAR, local allergic rhinitisLocal allergic rhinitisLocal IgENARES, non-allergic rhinitis with eosinophilia-syndromeNon-allergic-rhinitisNPT, nasal provocation testsPNIF, peak nasal inspiratory flowRAST, Radioallergosorbent TestSD, standard deviationsIgE, allergen-specific IgESPT, skin prick test

Identifiers

PMID32612737
PMCPMC7322186
OpenAlexW3037724157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.