ArticleFrontiers in neuroscience2020
Reorganization of Brain White Matter in Persistent Idiopathic Tinnitus Patients Without Hearing Loss: Evidence From Baseline Data.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Diffusion Tensor Imaging as a Tool to Evaluate the Cognitive Function of Patients With Vascular Dementia: A Meta-Analysis.The neurologist · 2023Pooled it
- White Matter Alterations Are More Robust Than Gray Matter Differences in Tinnitus and Hearing Loss: An MRI Study of Military Personnel.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Whole-Brain Structural Connectivity Alterations in Chronic Subjective Tinnitus: An Exploratory Diffusion Tensor Imaging Study.Brain sciences · 2026Article
- Pilot evaluation of transcutaneous vagus nerve stimulation in chronic tinnitus: clinical outcomes and DTI insights.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Cerebral blood flow alterations in non-auditory tinnitus: implications for cerebral venous congestion pathophysiology.Brain imaging and behavior · 2026Article
- Functional Connectivity Alterations and Molecular Characterization of the Anterior Cingulate Cortex in Tinnitus Pathology without Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review and Perspective on Brain Bases of Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- An MR spectroscopy study of temporal areas excluding primary auditory cortex and frontal regions in subjective bilateral and unilateral tinnitus.Scientific reports · 2023Article
- The characteristics of brain structural remodeling in patients with unilateral vestibular schwannoma.Journal of neuro-oncology · 2023Article
- The effect of aging, hearing loss, and tinnitus on white matter in the human auditory system revealed with fixel-based analysis.Frontiers in aging neuroscience · 2023Article
- Audiological and Other Factors Predicting the Presence of Misophonia Symptoms Among a Clinical Population Seeking Help for Tinnitus and/or Hyperacusis.Frontiers in neuroscience · 2022Article
- A large-scale diffusion imaging study of tinnitus and hearing loss.Scientific reports · 2021Article
- Pretreatment intranetwork connectivity can predict the outcomes in idiopathic tinnitus patients treated with sound therapy.Human brain mapping · 2021Article
- Outcomes at 6 months are related to brain structural and white matter microstructural reorganization in idiopathic tinnitus patients treated with sound therapy.Human brain mapping · 2021Article
- Cortical Thickness Alterations in Patients With Tinnitus Before and After Sound Therapy: A Surface-Based Morphometry Study.Frontiers in neuroscience · 2021Article
- Brain Structural and Functional Reorganization in Tinnitus Patients Without Hearing Loss After Sound Therapy: A Preliminary Longitudinal Study.Frontiers in neuroscience · 2021Article
- The Neural Mechanisms of Tinnitus: A Perspective From Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Review
- Surface-Based Amplitude of Low-Frequency Fluctuation Alterations in Patients With Tinnitus Before and After Sound Therapy: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
- Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study.Frontiers in human neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It remains unknown whether tinnitus or tinnitus-related hearing loss (HL) could indirectly impair or reshape the white matter (WM) of the human brain. We aim to explore the possible brain WM change in tinnitus patients without HL and further to investigate their associations with clinical variables. Structural and diffusion tensor imaging (DTI) of 20 idiopathic tinnitus patients without HL and 22 healthy controls (HCs) were obtained. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis were conducted to investigate the differences in WM volume and integrity between patients and HCs, separately. We extracted WM parameters to determine a sensitive imaging index to differentiate the idiopathic tinnitus patients from the HCs in the early stage. Correlations between the clinical variables and WM indices were also performed in patients. Compared with the controls, the tinnitus patients without HL exhibited significant decreased fractional anisotropy (FA) in the body and genu of corpus callosum (CC), left cingulum (LC) and right cingulum (RC), and right superior longitudinal fasciculus (RSLF) and increase in mean diffusivity (MD) in the body of CC in WM. Moreover, the patients also showed decreases in WM axial diffusivity (AD) in LC, left superior longitudinal fasciculus (LSLF), and right interior cerebellar peduncle (ICP) and increases in radial diffusivity (RD) in the body and genu of CC and RSLF (
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