ArticleThe Eurasian journal of medicine2020
Paraoxonase Activity and Phenotype Distribution in Patients with Chronic Obstructive Pulmonary Disease.
Article in The Eurasian journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Impact of smoking on redox homeostasis and 8-OHdG levels in COPD patients: a cross-sectional comparative study.BMC pulmonary medicine · 2025Article
- Bioinformatic Insights and XGBoost Identify Shared Genetics in Chronic Obstructive Pulmonary Disease and Type 2 Diabetes.The clinical respiratory journal · 2025Article
- Serum paraoxonase-1 as a marker of oxidative stress and pulmonary dysfunction in sarcoidosis: association with disease activity and prognostic potential.Frontiers in immunology · 2025Article
- Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge.Frontiers in physiology · 2024Review
- Contribution of cuproptosis and Cu metabolism-associated genes to chronic obstructive pulmonary disease.Journal of cellular and molecular medicine · 2023Review
- Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases.International journal of molecular sciences · 2023Review
- Suppressed paraoxonase-1 activity associates with elevated oxylipins and the presence of small airways disease in patients with rheumatoid arthritis.Clinical rheumatology · 2023Article
- Paraoxonase-1 Concentrations in Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
- Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis.Antioxidants (Basel, Switzerland) · 2021Review
- The Role of Oxidative Stress in Sarcoidosis.International journal of molecular sciences · 2021Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveParaoxonase 1 (PON1) and arylesterase (ARE) enzymes have an important role in the prevention of oxidative stress which is related to the pathogenesis of chronic obstructive pulmonary disease (COPD). PON1 levels vary widely among individuals and ethnic groups, which is in part associated with polymorphisms. MATERIALS AND
methodsWe investigated PON1 and ARE activity and phenotype distribution in COPD patients and healthy individuals. Sixty six COPD patients and 59 control subjects were involved in the study. Serum PON1 and ARE activities were detected by spectrophotometric method. The ratio of salt-induced PON1 to ARE activity was used to determine phenotypes as QQ, QR, and RR.
resultsCOPD patients exhibited higher PON1 activity (199.1 vs 129.2, p=0.002) but lower ARE activity compared to control (21.3 vs 33.5, p=0.021). There was a significant difference between COPD and control group with respect to PON1 phenotype characteristics. RR phenotypic distribution was more common in the COPD group than in control (60.6% [95% CI: 48.8 - 72.3] versus 22.0 % [95% CI: 12.0 - 31.9], p=0.001). We also found that smoking (95.0% CI: 0.001-0.036, p<0.001) and RR phenotype (95.0% CI: 0.006 - 0.59, p=0.016) are independent determinants in COPD.
conclusionWe found that RR phenotype was more common in COPD patients compared to control. Smoking and RR phenotype may be defined as independent factors associated with COPD.
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