Evidence map›Paper›PMID 32612285›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2020

Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice.

Karuna Irungbam, Martin Roderfeld, Hannah Glimm, Felix Hempel, Franziska Schneider, Laura Hehr, Dieter Glebe, Yuri Churin, Gertrud Morlock, Imanuel Yüce and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Metabolic reprogramming of hepatocytes byJHEP reports : innovation in hepatology · 2023
    Article
  6. Article
  7. Fructose and Non-Alcoholic Steatohepatitis.Frontiers in pharmacology · 2021
    Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Karuna IrungbamDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.
Martin RoderfeldDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0002-3232-1277
Hannah GlimmDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.
Felix HempelDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0002-2733-4313
Franziska SchneiderDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.
Laura HehrDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.
Dieter GlebeInstitute of Medical Virology, National Reference Centre for Hepatitis B Viruses and Hepatitis D Viruses, Justus Liebig University, Giessen, Germany.
Yuri ChurinDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0002-0065-0252
Gertrud MorlockInstitute of Nutritional Science, Chair of Food Science, and TransMIT Center for Effect-Directed Analysis, Justus Liebig University Giessen, Giessen, Germany.
Imanuel YüceInstitute of Nutritional Science, Chair of Food Science, and TransMIT Center for Effect-Directed Analysis, Justus Liebig University Giessen, Giessen, Germany.
Elke RoebDepartment of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany. elke.roeb@innere.med.uni-giessen.de.
Justus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies demonstrated that nonalcoholic steatohepatitis is associated with liver-related outcomes in chronic hepatitis B. Furthermore, primary biliary fibrosis and biliary atresia occurred in patients with HBV infection. Interestingly, hepatitis B virus surface protein (HBs) transgenic mice spontaneously develop hepatic steatosis. Our aim is to investigate the effect of Abcb4 knockout-induced cholestasis on liver steatosis in HBs transgenic mice. Hybrids of HBs transgenic and Abcb4

Indexed as

Lipid MetabolismAMP-Activated Protein KinasesAnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BCholestasisCyclic AMP Response Element-Binding ProteinFatty LiverFemaleHep G2 CellsHumansMaleMice, Inbred BALB CMice, KnockoutPerilipin-2TriglyceridesAMP-Activated Protein KinasesATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BCyclic AMP Response Element-Binding ProteinPerilipin-2Plin2 protein, mouseTriglycerides

Identifiers

PMID32612285
PMCPMC7572243
OpenAlexW3039747720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.