Evidence map›Paper›PMID 32612237›Full record

ArticleNature2020

Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.

Anna B Loveland, Gabriel Demo, Andrei A Korostelev

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 132 citations in OpenAlex.

  1. Recoding by NNature communications · 2026
    Article
  2. eLife · 2026
    Article
  3. Article
  4. RNAViruses · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Mechanistic insights intobioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Doublet decoding of tRNANature communications · 2025
    Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Anna B LovelandRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.
Gabriel DemoRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-5472-9249
Andrei A KorostelevRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA. andrei.korostelev@umassmed.edu.ORCID http://orcid.org/0000-0003-1588-717X
University of Massachusetts Chan Medical School · USCentral European Institute of Technology · CZ

Funding

Translational Control: Discovery and MechanismsR35GM127094 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Andrei Korostelev · 2018 to 2026
$5.5M
Structural bases for cellular stress responses mediated by stalled translationR01GM106105 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KOROSTELEV, ANDREI · 2013 to 2017
$1.6M
Molecular principles of translation terminationR01GM107465 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KOROSTELEV, ANDREI · 2015 to 2018
$1.3M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM106105NIGMS NIH HHS R01 GM107465NIGMS NIH HHS R35 GM127094
6 · The paper itself

Abstract

Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA that is delivered by the elongation factor EF-Tu

Indexed as

Cryoelectron MicroscopyEscherichia coliGTP PhosphohydrolasesGuanosine DiphosphateGuanosine TriphosphateHydrolysisModels, MolecularPeptide Elongation Factor TuRibosomesRNA, MessengerRNA, TransferRotationGTP PhosphohydrolasesGuanosine DiphosphateGuanosine TriphosphatePeptide Elongation Factor TuRNA, MessengerRNA, Transfer

Identifiers

PMID32612237
PMCPMC7483604
OpenAlexW3039911054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.