ArticleNature2020
Physiological blood-brain transport is impaired with age by a shift in transcytosis.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed, 1 pooled it
24.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
292 citing papers in PubMed, 1 synthesis or guideline pooled it, 460 citations in OpenAlex.
- Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood-brain barrier.Nature biomedical engineering · 2025Pooled it
- The sleep-deprived blood-brain barrier: Does the Brain's gatekeeper adapt or merely fail slowly?Neurobiology of sleep and circadian rhythms · 2026Review
- A roadmap towards clinical use of molecular biomarkers in acute ischaemic stroke.Nature reviews. Neurology · 2026Review
- Pharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease.Inflammopharmacology · 2026Review
- From Design to Bedside: Brain-Targeted Engineered Nanoparticles and Predictive Modeling for Neurodegenerative Diseases Therapeutics.Pharmaceutical research · 2026Review
- Neurovascular Unit Dysfunction and Neural Barrier Pathology in Dysautonomia: Molecular Links to Cardiovascular Autonomic Failure.International journal of molecular sciences · 2026Review
- Huntington's disease vasculopathy is barrier-type-selective and arteriolar-dominant with spatially-coupled astrogliosis and reversible by S1pr1 stimulation.Nature communications · 2026Article
- Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- VINE-seq and MultiVINE-seq for single-nucleus and multiome profiling of the brain vasculature.Nature protocols · 2026Review
- Evaluating the effects of aging on distribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics.Nature chemical biology · 2026Article
- Review
- Review
- Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice.Nature communications · 2026Article
- The bone-cerebrovascular axis: effects of bone aging on neurovascular dysfunction and neurodegeneration.The Journal of clinical investigation · 2026Review
- Chemotherapy neurotoxicity and aging: Uncovering shared central nervous system pathologies and potential interventions.Neuro-oncology advances · 2026Review
- An irradiation-free platform for localized skull bone marrow manipulation to dissect the skull-brain axis.Journal of neuroinflammation · 2026Article
- Comparative Analysis of Regional Blood-Brain Barrier Permeability in Humans and Rodents: An Evolutionary Perspective.Research square · 2026Article
- Peripheral immunosenescence biomarkers and longitudinal cognitive decline: a large population-based study.npj aging · 2026Article
232 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 5 institutions in 1 country.
Andrew C YangDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6756-4746
Marc Y StevensDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Michelle B ChenDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.
Davis P LeeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Daniel StähliDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
David GateDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0481-9657
Kévin ContrepoisDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9678-5161
Winnie ChenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Tal IramDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Lichao ZhangChan Zuckerberg Biohub, Stanford, CA, USA.
Ryan T VestDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Aisling ChaneyDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Benoit LehallierDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Niclas OlssonDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9746-0542
Haley du BoisDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Ryan HsiehDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Haley C CropperDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Daniela BerdnikDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7452-3785
Lulin LiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Elizabeth Y WangDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Gavin M TraberDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3494-9196
Carolyn R BertozziChEM-H, Stanford University, Stanford, CA, USA.
Jian LuoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2064-8467
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0784-7987
Joshua E EliasChan Zuckerberg Biohub, Stanford, CA, USA.
Stephen R QuakeDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1613-0809
Michelle L JamesDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Tony Wyss-CorayChEM-H, Stanford University, Stanford, CA, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831
Stanford University · USChan Zuckerberg Initiative (United States) · USNeurosciences Institute · USHoward Hughes Medical Institute · USStanford Medicine · US
Funding
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Victor Henderson · 2020 to 2026
$29.0MSpecial EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2MInvestigations of Golgi EnzymesR01GM059907 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BERTOZZI, CAROLYN · 1999 to 2016
$5.9MStanford Training Program in Aging ResearchT32AG047126 · NIA · STANFORD UNIVERSITY · PI VYJEYANTHI S PERIYAKOIL, TONY WYSS-CORAY · 2014 to 2026
$4.3MInvestigating the Surface GlycoproteomeR01CA200423 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2015 to 2026
$3.8MA Bioorthogonal Approach to Study Mammalian AgingDP1AG053015 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2015 to 2019
$3.7MTargeting Cerebrovascular TGF Signaling in Alzheimer's DiseaseRF1AG059694 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI LUO, JIAN, WYSS-CORAY, TONY · 2018 to 2018
$3.0MPredoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2MLightsheet Microscope for Large-Scale Imaging of Cleared Tissue SamplesS10OD025091 · OD · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2018 to 2018
$337kNCI NIH HHS R01 CA200423NHGRI NIH HHS P50 HG007735NIA NIH HHS 1RF1AG059694NIA NIH HHS DP1 AG053015NIA NIH HHS P30 AG066515NIA NIH HHS RF1 AG059694NIA NIH HHS T32 AG047126NIGMS NIH HHS R01 GM059907NIGMS NIH HHS T32 GM099608NIH HHS 3P50HG00773505S1NIH HHS S10 OD025091
Abstract
The vascular interface of the brain, known as the blood-brain barrier (BBB), is understood to maintain brain function in part via its low transcellular permeability
Indexed as
TranscytosisAgingAlkaline PhosphataseAnimalsAntibodiesBiological TransportBlood-Brain BarrierBlood ProteinsBrainDrug Delivery SystemsHealthHumansMaleMiceMice, Inbred C57BLPlasmaAlkaline PhosphataseALPL protein, mouseAntibodiesBlood ProteinsProteomeReceptors, TransferrinTransferrin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.