Evidence map›Paper›PMID 32612190›Full record

ArticleScientific reports2020

Role of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme.

Manpreet Kaur, Baljit Kaur, Jagroop Kaur, Anudeep Kaur, Rajbir Bhatti, Palwinder Singh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Manpreet KaurUGC Sponsored Centre for Advanced Studies, Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India.
Baljit KaurUGC Sponsored Centre for Advanced Studies, Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India.
Jagroop KaurUGC Sponsored Centre for Advanced Studies, Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India.
Anudeep KaurDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.
Rajbir BhattiDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.
Palwinder SinghUGC Sponsored Centre for Advanced Studies, Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India. palwinder_singh_2000@yahoo.com.
Guru Nanak Dev University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While designing the anti-inflammatory agents targeting cyclooxygenase-2 (COX-2), we first identified a water loop around the heme playing critical role in the enzyme catalysis. The results of molecular dynamic studies supported by the strong hydrogen-bonding equilibria of the participating atoms, radical stabilization energies, the pK

Indexed as

AnalgesicsAnimalsAnti-Inflammatory AgentsCarrageenanCatalysisCyclooxygenase 2Cyclooxygenase 2 InhibitorsDrug DesignElectronsFemaleFormaldehydeHemeHydrogenHydrogen-Ion ConcentrationInflammationInhibitory Concentration 50AnalgesicsAnti-Inflammatory AgentsCarrageenanCyclooxygenase 2Cyclooxygenase 2 InhibitorsFormaldehydeHemeHydrogenPeptidesWater

Identifiers

PMID32612190
PMCPMC7329864
OpenAlexW3038293980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.