Evidence map›Paper›PMID 32612165›Full record

ArticleScientific reports2020

Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in hippocampus.

Masako Nakano, Kenta Kubota, Eiji Kobayashi, Takako S Chikenji, Yuki Saito, Naoto Konari, Mineko Fujimiya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 4 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 4 syntheses or guidelines pooled it, 220 citations in OpenAlex.

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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Masako NakanoDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan. m.nakano@sapmed.ac.jp.
Kenta KubotaDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Eiji KobayashiDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Takako S ChikenjiDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Yuki SaitoDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Naoto KonariDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Mineko FujimiyaDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Sapporo Medical University · JPHealth Sciences University of Hokkaido · JPHokkaido Bunkyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) ameliorates diabetes-induced cognitive impairment by transferring exosomes derived from these cells into astrocytes. Here, we show that intracerebroventricularly injected BM-MSCs improve cognitive impairment in AD model mice by ameliorating astrocytic inflammation as well as synaptogenesis. Although AD model mice showed an increase in NF-κB in the hippocampus, BM-MSC-treated AD model mice did not show this increase but showed an increase in levels of microRNA (miR)-146a in the hippocampus. Intracerebroventricularly injected BM-MSCs were attached to the choroid plexus in the lateral ventricle, and thus, BM-MSCs may secrete exosomes into the cerebrospinal fluid. In vitro experiments showed that exosomal miR-146a secreted from BM-MSCs was taken up into astrocytes, and an increased level of miR-146a and a decreased level of NF-κB were observed in astrocytes. Astrocytes are key cells for the formation of synapses, and thus, restoration of astrocytic function may have led to synaptogenesis and correction of cognitive impairment. The present study indicates that exosomal transfer of miR-146a is involved in the correction of cognitive impairment in AD model mice.

Indexed as

Mesenchymal Stem Cell TransplantationAlzheimer DiseaseAnimalsAstrocytesBone Marrow CellsChoroid PlexusCognition DisordersCognitive DysfunctionDisease Models, AnimalExosomesGlial Fibrillary Acidic ProteinHippocampusInflammationMacrophagesMaleMaze LearningGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseMicroRNAsMirn146 microRNA, mouseNF-kappa B

Identifiers

PMID32612165
PMCPMC7330036
OpenAlexW3038295907

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.