Evidence map›Paper›PMID 32612160›Full record

ArticleMucosal immunology2021

Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity.

Xinyi Qi, Jinxin Qiu, Jiali Chang, Yan Ji, Qi Yang, Guoliang Cui, Liming Sun, Qian Chai, Jun Qin, Ju Qiu

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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  15. Innate Lymphoid Cells and Intestinal Inflammatory Disorders.International journal of molecular sciences · 2022
    Review
  16. Review
  17. Epigenome-metabolome-microbiome axis in health and IBD.Current opinion in microbiology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Xinyi QiCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai Jiao Tong University School of Medicine (SJTUSM), 200031, Shanghai, China.
Jinxin QiuCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Jiali ChangCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Yan JiCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Qi YangDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY, 12208, USA.
Guoliang CuiT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Liming SunState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
Qian ChaiKey Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Jun QinCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China. qinjun@sibs.ac.cn.
Ju QiuCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China. qiuju@sibs.ac.cn.ORCID http://orcid.org/0000-0002-1543-5678
Shanghai Institute of Nutrition and Health · CNAlbany Medical Center Hospital · USCenter for Excellence in Molecular Cell Science · CNChinese Academy of Sciences · CNGerman Cancer Research Center · DEShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and function of various immune cells. Here, by genetic deletion of Brg1 in ILC3s (Smarca4

Indexed as

Immunity, InnateImmunity, MucosalImmunomodulationAnimalsAntigens, LyDNA HelicasesHomeostasisIntestinal MucosaIntestinesLymphocyte SubsetsMiceNatural Cytotoxicity Triggering Receptor 1Nuclear ProteinsT-bet Transcription FactorT-Box Domain ProteinsTranscription FactorsAntigens, LyDNA HelicasesNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseNuclear ProteinsSmarca4 protein, mouseT-bet Transcription FactorT-Box Domain ProteinsTranscription Factors

Identifiers

PMID32612160
PMCPMC7790751
OpenAlexW3040290287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.