Evidence map›Paper›PMID 32611818›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Dynamic neural and glial responses of a head-specific model for traumatic brain injury in

Janani Saikumar, China N Byrns, Matthew Hemphill, David F Meaney, Nancy M Bonini

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  6. Review
  7. Article
  8. Study of Axonal Injury and Degeneration inCold Spring Harbor protocols · 2025
    Article
  9. Article
  10. Article
  11. TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity inInternational journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Janani SaikumarDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-8930-2472
China N ByrnsNeuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-8091-9353
Matthew HemphillDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.
David F MeaneyDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-0954-4122
Nancy M BoniniDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104; nbonini@sas.upenn.edu.ORCID 0000-0003-0226-5291
University of Pennsylvania · US

Funding

Molecular Genetic Insight into Neurodegenerative Disease from DrosophilaR35NS097275 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BONINI, NANCY M · 2017 to 2024
$6.0M
Mechanisms of remodeling circuit connectivity after traumatic brain injuryR01NS088176 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MEANEY, DAVID F · 2015 to 2018
$1.4M
Mechanisms of remodeling circuit connectivity after traumatic brain injuryR56NS088176 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MEANEY, DAVID F · 2014 to 2014
$400k
Howard Hughes Medical InstituteNINDS NIH HHS R01 NS088176NINDS NIH HHS R35 NS097275NINDS NIH HHS R56 NS088176
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated development of neurodegenerative diseases. There are currently no therapeutics to address this due to lack of insight into mechanisms of injury progression, which are challenging to study in mammalian models. Here, we have developed and extensively characterized a head-specific approach to TBI in

Indexed as

AnimalsBehavior, AnimalBrainBrain Injuries, TraumaticDisease Models, AnimalDrosophilaHeadHumansMaleNeurodegenerative DiseasesNeurogliaStress, PhysiologicalDrosophilaglial responseneural injurystress responsetraumatic brain injury

Identifiers

PMID32611818
PMCPMC7382229
OpenAlexW3040116780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.