ArticleProceedings of the National Academy of Sciences of the United States of America2020
Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Meta-analysis shows no consistent evidence for senescence in ejaculate traits across animals.Nature communications · 2024Pooled it
- Gut Metabolism Links Precision Nutrition, Exercise, and Healthspan in Drosophila melanogaster.Aging cell · 2026Article
- Mating-dependent lifespan cost of sterol depletion in maleProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sperm storage causes sperm senescence in human and non-human animals.Proceedings. Biological sciences · 2026Article
- No evidence lithium supplementation extends lifespan in male Drosophila melanogaster.Biogerontology · 2026Article
- Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird.Molecular ecology · 2026Article
- Gut metabolism links precision nutrition, exercise, and healthspan inbioRxiv : the preprint server for biology · 2025Article
- Diagnosing confounded Bateman gradients.Evolution; international journal of organic evolution · 2025Article
- Ejaculate Ejection by Female Fruit Flies Does Not Correlate With Mating Latency or Male Presence, Irrespective of How Ejection Is Measured.Ecology and evolution · 2025Article
- The Developmental Environment Mediates Adult Seminal Proteome Allocation in Male Drosophila melanogaster.Molecular ecology · 2025Article
- Reproductive output of old males is limited by seminal fluid, not sperm number.Evolution letters · 2025Article
- Male aging in germ cells: What are we inheriting?Genetics and molecular biology · 2025Article
- Fear of mating out (FOMO): voyeurism does not increase mating propensity in fruit flies.Scientific reports · 2024Article
- Article
- What does not kill you makes you stronger? Effects of paternal age at conception on fathers and sons.Evolution; international journal of organic evolution · 2024Article
- Ancestral lineages of dietary exposure to an endocrine disrupting chemical drive distinct forms of transgenerational subfertility in an insect model.Scientific reports · 2024Article
- Separation of reproductive decline from lifespan extension during methionine restriction.Nature aging · 2024Article
- Effects of an entomopathogenic fungus on the reproductive potential ofEcology and evolution · 2024Article
- Genotype-by-environment interactions influence the composition of theProceedings. Biological sciences · 2023Article
- Social group composition modulates the role of last male sperm precedence in post-copulatory sexual selection.Journal of evolutionary biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
Abstract
Declining ejaculate performance with male age is taxonomically widespread and has broad fitness consequences. Ejaculate success requires fully functional germline (sperm) and soma (seminal fluid) components. However, some aging theories predict that resources should be preferentially diverted to the germline at the expense of the soma, suggesting differential impacts of aging on sperm and seminal fluid and trade-offs between them or, more broadly, between reproduction and lifespan. While harmful effects of male age on sperm are well known, we do not know how much seminal fluid deteriorates in comparison. Moreover, given the predicted trade-offs, it remains unclear whether systemic lifespan-extending interventions could ameliorate the declining performance of the ejaculate as a whole. Here, we address these problems using
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.