Evidence map›Paper›PMID 32611812›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells.

Amrendra Kumar, Timothy M Hill, Laura E Gordy, Naveenchandra Suryadevara, Lan Wu, Andrew I Flyak, Jelena S Bezbradica, Luc Van Kaer, Sebastian Joyce

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Markers and makers of NKT17 cells.Experimental & molecular medicine · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Amrendra KumarDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232.ORCID 0000-0002-1191-5228
Timothy M HillDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0001-7658-811X
Laura E GordyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
Naveenchandra SuryadevaraDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0003-2571-1290
Lan WuDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0001-6032-083X
Andrew I FlyakDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
Jelena S BezbradicaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0003-1441-1727
Luc Van KaerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
Sebastian JoyceDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232; sebastian.joyce@vumc.org.ORCID 0000-0002-3183-1451
Vanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · USCalifornia Institute of Technology · USUnited States Military Academy · USUniversity of Oxford · GB

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
MOLECULAR BASIS OF CDLDL AND NATURAL T CELL FUNCTIONR01AI042284 · NIAID · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 1998 to 2013
$3.1M
Role of autophagy-related protein Vps34 in antigen presentation and self-toleranceR01AI139046 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VAN KAER, LUC · 2019 to 2023
$2.2M
Molecular Basis of CD1D and Natural Killer T Cell FunctionR01AI137082 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JOYCE, SEBASTIAN · 2019 to 2022
$2.1M
Molecular Basis of iNKT Cell Ontogeny and FunctionR01AI061721 · NIAID · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 2006 to 2010
$2.1M
Glycolipid-Reactive NKT Cells, Obesity and Insulin ResistanceR01DK081536 · NIDDK · VANDERBILT UNIVERSITY · PI VAN KAER, LUC, WU, LAN · 2010 to 2013
$1.3M
iCD8alpha cells as novel innate-type lymphoid cells that mediate gut immunityR01DK104817 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VAN KAER, LUC · 2015 to 2018
$1.3M
Molecular Basis of CD1d1 and Natural T Cell FunctionR21AI042284 · NIAID · VANDERBILT UNIVERSITY · PI JOYCE, SEBASTIAN · 2002 to 2002
$302k
American Heart Association-American Stroke Association 19TPA34910078BLRD VA I01 BX001444BLRD VA I01 BX006010BLRD VA IK6 BX004595Medical Research Council MR/S000623/1NCI NIH HHS P30 CA068485NIAID NIH HHS R01 AI042284NIAID NIH HHS R01 AI061721NIAID NIH HHS R01 AI137082NIAID NIH HHS R01 AI139046NIAID NIH HHS R21 AI042284NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK081536NIDDK NIH HHS R01 DK104817
6 · The paper itself

Abstract

Semi-invariant natural killer T (iNKT) cells are self-reactive lymphocytes, yet how this lineage attains self-tolerance remains unknown. iNKT cells constitutively express high levels of

Indexed as

Cell DifferentiationImmune ToleranceNatural Killer T-CellsNuclear Receptor Subfamily 4, Group A, Member 1AnimalsCells, CulturedMiceMice, KnockoutReceptors, Antigen, T-CellThymocytesNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Receptors, Antigen, T-CelldevelopmentfunctioniNKT cellsNur77

Identifiers

PMID32611812
PMCPMC7382224
OpenAlexW3040249948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.