Evidence map›Paper›PMID 32611794›Full record

ArticleJournal of clinical microbiology2020

Gold Standard Cholera Diagnostics Are Tarnished by Lytic Bacteriophage and Antibiotics.

E J Nelson, J A Grembi, D L Chao, J R Andrews, L Alexandrova, P H Rodriguez, V V Ramachandran, M A Sayeed, J F Wamala, A K Debes and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Molecular Methods to DetectmedRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Dynamics of IgM and IgA Antibody Response Profile AgainstInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Effectiveness of the Euvichol® oral cholera vaccine at 2 years: A case-control and bias-indicator study in Haiti.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  11. Article
  12. Article
  13. Cholera Rapid Diagnostic Tests for the Detection ofDiagnostics (Basel, Switzerland) · 2021
    Review
  14. Bacteriophage ICP1: A Persistent Predator ofAnnual review of virology · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

E J NelsonDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, Florida, USA eric.nelson@ufl.edu.ORCID 0000-0003-2649-2624
J A GrembiDepartment of Civil and Environmental Engineering, Stanford University, Stanford, California, USA.
D L ChaoInstitute for Disease Modeling, Bellevue, Washington, USA.
J R AndrewsDepartment of Medicine, School of Medicine, Stanford University, Stanford, California, USA.
L AlexandrovaVincent Coates Foundation Mass Spectrometry Laboratory, Stanford University, Stanford, California, USA.
P H RodriguezDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, Florida, USA.
V V RamachandranDepartment of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA.
M A SayeedDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, Florida, USA.
J F WamalaCountry Preparedness and IHR (CPI), World Health Organization (South Sudan), Juba, South Sudan.
A K DebesJohns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
D A SackJohns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
A J HryckowianDepartment of Microbiology, School of Medicine, Stanford University, Stanford, California, USA.
F HaqueInstitute of Epidemiology, Disease Control and Research, Ministry of Health and Family Welfare, Government of Bangladesh, Dhaka, Bangladesh.
S KhatunInstitute of Epidemiology, Disease Control and Research, Ministry of Health and Family Welfare, Government of Bangladesh, Dhaka, Bangladesh.
M RahmanInstitute of Epidemiology, Disease Control and Research, Ministry of Health and Family Welfare, Government of Bangladesh, Dhaka, Bangladesh.
A ChienVincent Coates Foundation Mass Spectrometry Laboratory, Stanford University, Stanford, California, USA.
A M SpormannDepartment of Civil and Environmental Engineering, Stanford University, Stanford, California, USA.
G K SchoolnikDepartment of Medicine, School of Medicine, Stanford University, Stanford, California, USA.
Stanford University · USInstitute of Epidemiology, Disease Control and Research · BDUniversity of Florida Health · USJohns Hopkins University · USBellevue Hospital Center · US

Funding

Epidemiology and Ecology of Cholera in AfricaR01AI123422 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Amanda Kay Debes, DAVID A SACK · 2017 to 2026
$6.6M
A novel approach to improve patient care and diarrheal disease research using mobile technologyDP5OD019893 · OD · UNIVERSITY OF FLORIDA · PI NELSON, ERIC JORGE · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI123422NIH HHS DP5 OD019893World Health Organization 001
6 · The paper itself

Abstract

A fundamental, clinical, and scientific concern is how lytic bacteriophage, as well as antibiotics, impact diagnostic positivity. Cholera was chosen as a model disease to investigate this important question, because cholera outbreaks enable large enrollment, field methods are well established, and the predatory relationship between lytic bacteriophage and the etiologic agent

Indexed as

BacteriophagesCholeraVibrio choleraeAnti-Bacterial AgentsBangladeshDisease OutbreaksHumansAnti-Bacterial AgentsbacteriophagecholeracholeraeICP1ICP2ICP3outbreakRDTvibriovibriophage

Identifiers

PMID32611794
PMCPMC7448619
OpenAlexW3038204676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.